| Tag | Content |
|---|
| CPLM ID | CPLM-011544 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Probable phosphatase PSR2 |
Protein Synonyms/Alias | Plasma membrane sodium response protein 2 |
Gene Name | PSR2 |
Gene Synonyms/Alias | YLR019W |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 56 | KATPNGDKMQYSTPE | ubiquitination | [1] | | 90 | NGNSGNGKLAPLSRD | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Probable phosphatase. Involved in the response to sodium and lithium ion stress (but not to potassium or sorbitol stress) by inducing transcription of the sodium pump ENA1/PMR2. Acts through a calcineurin-independent pathway and is functionally redundant with PSR1. Also involved in the general stress response; acts together with WHI2 to activate stress response element (STRE)-mediated gene expression, possibly through dephosphorylation of MSN2. |
Sequence Annotation | DOMAIN 223 381 FCP1 homology.
LIPID 9 9 S-palmitoyl cysteine (Potential).
LIPID 10 10 S-palmitoyl cysteine (Potential). |
Keyword | Cell membrane; Complete proteome; Hydrolase; Lipoprotein; Membrane; Palmitate; Protein phosphatase; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 397 AA |
Protein Sequence | MGFIANILCC SSDTSKTHRQ RQPPETNHNR NRNRKHSSNK AQTQGRKQKA TPNGDKMQYS 60
TPEILLSSSD SGSNAGSKTM QENGNSGNGK LAPLSRDHSN NSYDEEKEYE DYNEGDVEMT 120
EVNNAGEEEE EDDEAKEKQD HVVHEYNVDA DRNSSINDEA PPQQGLYQVG QEDMNPQYVA 180
SSPDNDLNLI PTTEEDFSDL THLQPDQYHA PGYDTLLPPK LQEFQQKKCL ILDLDETLVH 240
SSFKYMHSAD FVLPVEIDDQ VHNVYVIKRP GVDEFLNRVS QLYEVVVFTA SVSRYANPLL 300
DTLDPNGTIH HRLFREACYN YEGNYIKNLS QIGRPLSETI ILDNSPASYI FHPQHAVPIS 360
SWFSDTHDNE LLDIIPLLED LSSGNVLDVG SVLDVTI 397 |
Gene Ontology | GO:0005886; C:plasma membrane; ISS:UniProtKB. GO:0004721; F:phosphoprotein phosphatase activity; ISS:SGD. GO:0009408; P:response to heat; IMP:UniProtKB. GO:0009651; P:response to salt stress; IMP:UniProtKB. |
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Pfam | |
SMART | |
PROSITE | |
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