UniProt Accession

 ADAP1_HUMAN; O75689; A4D2Q2 

Genbank Protein ID

 AJ006422; AF082324; AB097049; CH236965; CH471144; BC033747 

Genbank Nucleotide ID

 CAA07024.1; AAD11414.1; BAC77402.1; EAL23709.1; EAW87183.1; AAH33747.1 

Protein Name

 Arf-GAP with dual PH domain-containing protein 1 

Protein Synonyms/Alias

 Centaurin-alpha-1; Cnt-a1; Putative MAPK-activating protein PM25 

Gene Name

 ADAP1 

Gene Synonyms/Alias

 CENTA1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
123	QEFIYPEKQEPYSAG	ubiquitination	[1]
272	KQTEGFRKRWFTMDD	acetylation	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 

Functional Description

 GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol 3,4,5- trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). 

Sequence Annotation

 DOMAIN 7 126 Arf-GAP.
 DOMAIN 129 230 PH 1.
 DOMAIN 252 356 PH 2.
 ZN_FING 21 44 C4-type.
 MOD_RES 87 87 Phosphoserine; by PKC.
 MOD_RES 272 272 N6-acetyllysine.
 MOD_RES 276 276 Phosphothreonine; by PKC.  

Keyword

 3D-structure; Acetylation; Complete proteome; Cytoplasm; GTPase activation; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 374 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0005886; C:plasma membrane; IDA:UniProtKB.
 GO:0008060; F:ARF GTPase activator activity; IDA:UniProtKB.
 GO:0043533; F:inositol 1,3,4,5 tetrakisphosphate binding; TAS:UniProtKB.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0007166; P:cell surface receptor signaling pathway; TAS:ProtInc.
 GO:0032312; P:regulation of ARF GTPase activity; IEA:InterPro. 

Interpro

 IPR001164; ArfGAP.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology. 

Pfam

 PF01412; ArfGap
 PF00169; PH 

SMART

 SM00105; ArfGap
 SM00233; PH 

PROSITE

 PS50115; ARFGAP
 PS50003; PH_DOMAIN 

PRINTS

 PR00405; REVINTRACTNG.