Tag | Content |
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CPLM ID | CPLM-013360 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | RNA-binding motif protein, X chromosome |
Protein Synonyms/Alias | Heterogeneous nuclear ribonucleoprotein G; hnRNP G; RNA-binding motif protein, X chromosome retrogene; RNA-binding motif protein, X chromosome retrogene-like; RNA-binding motif protein, X chromosome, N-terminally processed |
Gene Name | Rbmx |
Gene Synonyms/Alias | Rbmxrt |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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63 | FESPADAKDAARDMN | acetylation | [1] |
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Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'- CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non- specifically to pre-mRNAs. Plays also a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. |
Sequence Annotation | DOMAIN 8 86 RRM. MOD_RES 1 1 N-acetylmethionine; in Heterogeneous MOD_RES 2 2 N-acetylvaline; in Heterogeneous nuclear MOD_RES 30 30 N6-acetyllysine (By similarity). MOD_RES 88 88 Phosphoserine (By similarity). MOD_RES 168 168 Phosphoserine (By similarity). MOD_RES 185 185 Omega-N-methylated arginine (By MOD_RES 208 208 Phosphoserine (By similarity). MOD_RES 329 329 Phosphoserine (By similarity). MOD_RES 332 332 Phosphoserine (By similarity). MOD_RES 352 352 Phosphoserine (By similarity). |
Keyword | Acetylation; Complete proteome; Direct protein sequencing; Glycoprotein; Methylation; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Repressor; Ribonucleoprotein; RNA-binding; Spliceosome; Transcription; Tumor suppressor. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 390 AA |
Protein Sequence | MVEADRPGKL FIGGLNTETN EKALEAVFGK YGRIVEVLLM KDRETNKSRG FAFVTFESPA 60 DAKDAARDMN GKSLDGKAIK VEQATKPSFE SGRRGLPPPP RSRGPPRGLR GGRGGSGGTR 120 GPPSRGGHMD DGGYSMNFTL SSSRGPLPVK RGPPPRSGGP PPKRSAPSGP VRSSSGMGGR 180 APVSRGRDGY GGPPRREPLP SRRDVYLSPR DDGYSTKDSY SSRDYPSSRD TRDYAPPPRD 240 YTYRDYGHSS SRDDYPSRGY SDRDGYGRER DYSDHPSGGS YRDSYESYGN SRSAPPTRGP 300 PPSYGGSSRY DDYSSSRDGY GGSRDSYTSS RSDLYSSGRD RVGRQERGLP PSMERGYPPP 360 RDSYSSSSRG APRGGGRGGS RSDRGGRSRY 390 |
Gene Ontology | GO:0005681; C:spliceosomal complex; IDA:RGD. GO:0000166; F:nucleotide binding; IEA:InterPro. GO:0003727; F:single-stranded RNA binding; IDA:RGD. GO:0006376; P:mRNA splice site selection; IMP:RGD. GO:0045893; P:positive regulation of transcription, DNA-dependent; IMP:RGD. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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