UniProt Accession

 CTBL1_HUMAN; Q8WYA6; Q0VAL9; Q53HI8; Q5JWZ2; Q5JWZ3; Q5JWZ7; Q5JWZ8; Q8N454; Q8NCL2; Q8TBD6; Q96KD2; Q9H7A5; Q9NQF9; Q9NTX0; Q9Y3M7 

Genbank Protein ID

 AF239607; AF367471; AF370431; AK074663; AK024761; AL118499; AL023804; AL109964; AL118499; AL023804; AL109964; AL109964; AL023804; AL118499; AL109964; AL023804; AL109964; AL023804; AL118499; AL023804; AL109964; AL118499; AL023804; AL109964; AL023804; AL109964; AL118499; BC022802; BC121006; AK222592 

Genbank Nucleotide ID

 AAL69567.1; AAK53407.1; AAQ15267.1; BAC11121.1; BAB14992.1; CAI19331.1; CAI19331.1; CAI19331.1; CAI19332.1; CAI19332.1; CAI19332.1; CAI42203.1; CAI42203.1; CAI42203.1; CAI42204.1; CAI42204.1; CAI42208.1; CAI42208.1; CAI42208.1; CAI42984.1; CAI42984.1; CAI42984.1; CAI42985.1; CAI42985.1; CAI42986.1; CAI42986.1; CAI42986.1; AAH22802.1; AAI21007.1; BAD96312.1 

Protein Name

 Beta-catenin-like protein 1 

Protein Synonyms/Alias

 Nuclear-associated protein; NAP; Testis development protein NYD-SP19 

Gene Name

 CTNNBL1 

Gene Synonyms/Alias

 C20orf33; PP8304 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
91	KMILTFEKRSYKNQE	acetylation	[1]
332	SNRERFLKGEGLQLM	ubiquitination	[2, 3]
355	ISRSSALKVLDHAMI	ubiquitination	[3]
372	EGTDNCHKFVDILGL	ubiquitination	[3]
388	TIFPLFMKSPRKIKK	ubiquitination	[3]
395	KSPRKIKKVGTTEKE	ubiquitination	[3]
429	QRTRLLNKFTENDSE	ubiquitination	[3]
437	FTENDSEKVDRLMEL	ubiquitination	[3]
457	GAMQVADKKIEGEKH	ubiquitination	[3]
458	AMQVADKKIEGEKHD	ubiquitination	[3]
527	NMRGSSIKIVRHIIK	ubiquitination	[3]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis. 

Sequence Annotation

 MOTIF 16 33 Nuclear localization signal.
 MOD_RES 91 91 N6-acetyllysine.
 MOD_RES 389 389 Phosphoserine.
 MOD_RES 545 545 Phosphoserine (By similarity).  

Keyword

 Acetylation; Alternative splicing; Apoptosis; Complete proteome; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Spliceosome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 563 AA 

Protein Sequence

Gene Ontology

 GO:0000974; C:Prp19 complex; IDA:UniProtKB.
 GO:0005681; C:spliceosomal complex; IDA:UniProtKB.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0043065; P:positive regulation of apoptotic process; IDA:UniProtKB.
 GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
 GO:0016445; P:somatic diversification of immunoglobulins; IMP:UniProtKB. 

Interpro

 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR013180; DUF1716_euk. 

Pfam

 PF08216; DUF1716 

SMART

  

PROSITE

  

PRINTS