UniProt Accession

 TAF10_HUMAN; Q12962; O00703; Q13175; Q6FH13 

Genbank Protein ID

 U13991; U25816; AF498312; CR541943; CH471064; BC012088 

Genbank Nucleotide ID

 AAA62230.1; AAB61242.1; AAM14627.1; CAG46741.1; EAW68687.1; AAH12088.1 

Protein Name

 Transcription initiation factor TFIID subunit 10 

Protein Synonyms/Alias

 STAF28; Transcription initiation factor TFIID 30 kDa subunit; TAF(II)30; TAFII-30; TAFII30 

Gene Name

 TAF10 

Gene Synonyms/Alias

 TAF2A; TAF2H; TAFII30 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
161	LISLAAQKFISDIAN	ubiquitination	[1]
175	NDALQHCKMKGTASG	ubiquitination	[1]
177	ALQHCKMKGTASGSS	ubiquitination	[1]
189	GSSRSKSKDRKYTLT	methylation	[2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Gene-specific modulation of TAF10 function by SET9-mediated methylation.
 Kouskouti A, Scheer E, Staub A, Tora L, Talianidis I.
 Mol Cell. 2004 Apr 23;14(2):175-82. [PMID: 15099517] 

Functional Description

 TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. 

Sequence Annotation

 MOTIF 187 189 [KR]-[STA]-K motif.
 MOD_RES 2 2 N-acetylserine.
 MOD_RES 189 189 N6-methyllysine.  

Keyword

 3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Methylation; Nucleus; Polymorphism; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 218 AA 

Protein Sequence

Gene Ontology

 GO:0000125; C:PCAF complex; IDA:UniProtKB.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:HGNC.
 GO:0030914; C:STAGA complex; IDA:UniProtKB.
 GO:0005669; C:transcription factor TFIID complex; IDA:UniProtKB.
 GO:0033276; C:transcription factor TFTC complex; IDA:UniProtKB.
 GO:0030331; F:estrogen receptor binding; IDA:UniProtKB.
 GO:0070063; F:RNA polymerase binding; IDA:UniProtKB.
 GO:0003713; F:transcription coactivator activity; IDA:UniProtKB.
 GO:0016578; P:histone deubiquitination; IDA:UniProtKB.
 GO:0043966; P:histone H3 acetylation; IDA:UniProtKB.
 GO:0051260; P:protein homooligomerization; IDA:UniProtKB.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006368; P:transcription elongation from RNA polymerase II promoter; TAS:Reactome.
 GO:0006367; P:transcription initiation from RNA polymerase II promoter; IDA:UniProtKB.
 GO:0022415; P:viral reproductive process; TAS:Reactome. 

Interpro

 IPR003923; TFIID_30kDa. 

Pfam

 PF03540; TFIID_30kDa 

SMART

  

PROSITE

  

PRINTS

 PR01443; TFIID30KDSUB.