| Tag | Content |
|---|
| CPLM ID | CPLM-012073 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform |
Protein Synonyms/Alias | PP2A B subunit isoform B'-gamma; PP2A B subunit isoform B56-gamma; PP2A B subunit isoform PR61-gamma; PP2A B subunit isoform R5-gamma; Renal carcinoma antigen NY-REN-29 |
Gene Name | PPP2R5C |
Gene Synonyms/Alias | KIAA0044 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 6 | **MLTCNKAGSRMVV | ubiquitination | [1] | | 45 | QEKLFIQKLRQCCVL | ubiquitination | [1] | | 403 | LFMEMNQKLFDDCTQ | ubiquitination | [1] | | 432 | EREEAWVKIENLAKA | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage- induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation. |
Sequence Annotation | MOTIF 416 422 Nuclear localization signal (Potential).
MOD_RES 497 497 Phosphoserine (By similarity). |
Keyword | 3D-structure; Alternative splicing; Centromere; Chromosome; Complete proteome; Nucleus; Phosphoprotein; Polymorphism; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 524 AA |
Protein Sequence | MLTCNKAGSR MVVDAANSNG PFQPVVLLHI RDVPPADQEK LFIQKLRQCC VLFDFVSDPL 60
SDLKWKEVKR AALSEMVEYI THNRNVITEP IYPEVVHMFA VNMFRTLPPS SNPTGAEFDP 120
EEDEPTLEAA WPHLQLVYEF FLRFLESPDF QPNIAKKYID QKFVLQLLEL FDSEDPRERD 180
FLKTTLHRIY GKFLGLRAYI RKQINNIFYR FIYETEHHNG IAELLEILGS IINGFALPLK 240
EEHKIFLLKV LLPLHKVKSL SVYHPQLAYC VVQFLEKDST LTEPVVMALL KYWPKTHSPK 300
EVMFLNELEE ILDVIEPSEF VKIMEPLFRQ LAKCVSSPHF QVAERALYYW NNEYIMSLIS 360
DNAAKILPIM FPSLYRNSKT HWNKTIHGLI YNALKLFMEM NQKLFDDCTQ QFKAEKLKEK 420
LKMKEREEAW VKIENLAKAN PQYTVYSQAS TMSIPVAMET DGPLFEDVQM LRKTVKDEAH 480
QAQKDPKKDR PLARRKSELP QDPHTKKALE AHCRADELAS QDGR 524 |
Gene Ontology | GO:0000775; C:chromosome, centromeric region; IDA:UniProtKB. GO:0005634; C:nucleus; IDA:UniProtKB. GO:0000159; C:protein phosphatase type 2A complex; IDA:UniProtKB. GO:0008601; F:protein phosphatase type 2A regulator activity; IDA:UniProtKB. GO:0006977; P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; IDA:UniProtKB. GO:0042771; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; IMP:UniProtKB. GO:0008285; P:negative regulation of cell proliferation; IDA:UniProtKB. GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; IMP:MGI. GO:0007165; P:signal transduction; NAS:UniProtKB. |
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