CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023266
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transferrin receptor protein 2 
Protein Synonyms/Alias
 TfR2 
Gene Name
 TFR2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
609DTYENLHKVLQGRLPubiquitination[1, 2]
665NEFSGDLKARGLTLQubiquitination[3, 4]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
 Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. 
Sequence Annotation
 MOTIF 23 26 Endocytosis signal (Potential).
 CARBOHYD 240 240 N-linked (GlcNAc...) (Potential).
 CARBOHYD 339 339 N-linked (GlcNAc...).
 CARBOHYD 540 540 N-linked (GlcNAc...) (Potential).
 CARBOHYD 754 754 N-linked (GlcNAc...).
 DISULFID 108 108 Interchain (Potential).
 DISULFID 111 111 Interchain (Potential).  
Keyword
 Alternative splicing; Cell membrane; Complete proteome; Cytoplasm; Disease mutation; Disulfide bond; Glycoprotein; Membrane; Polymorphism; Receptor; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 801 AA 
Protein Sequence
MERLWGLFQR AQQLSPRSSQ TVYQRVEGPR KGHLEEEEED GEEGAETLAH FCPMELRGPE 60
PLGSRPRQPN LIPWAAAGRR AAPYLVLTAL LIFTGAFLLG YVAFRGSCQA CGDSVLVVSE 120
DVNYEPDLDF HQGRLYWSDL QAMFLQFLGE GRLEDTIRQT SLRERVAGSA GMAALTQDIR 180
AALSRQKLDH VWTDTHYVGL QFPDPAHPNT LHWVDEAGKV GEQLPLEDPD VYCPYSAIGN 240
VTGELVYAHY GRPEDLQDLR ARGVDPVGRL LLVRVGVISF AQKVTNAQDF GAQGVLIYPE 300
PADFSQDPPK PSLSSQQAVY GHVHLGTGDP YTPGFPSFNQ TQFPPVASSG LPSIPAQPIS 360
ADIASRLLRK LKGPVAPQEW QGSLLGSPYH LGPGPRLRLV VNNHRTSTPI NNIFGCIEGR 420
SEPDHYVVIG AQRDAWGPGA AKSAVGTAIL LELVRTFSSM VSNGFRPRRS LLFISWDGGD 480
FGSVGSTEWL EGYLSVLHLK AVVYVSLDNA VLGDDKFHAK TSPLLTSLIE SVLKQVDSPN 540
HSGQTLYEQV VFTNPSWDAE VIRPLPMDSS AYSFTAFVGV PAVEFSFMED DQAYPFLHTK 600
EDTYENLHKV LQGRLPAVAQ AVAQLAGQLL IRLSHDRLLP LDFGRYGDVV LRHIGNLNEF 660
SGDLKARGLT LQWVYSARGD YIRAAEKLRQ EIYSSEERDE RLTRMYNVRI MRVEFYFLSQ 720
YVSPADSPFR HIFMGRGDHT LGALLDHLRL LRSNSSGTPG ATSSTGFQES RFRRQLALLT 780
WTLQGAANAL SGDVWNIDNN F 801 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005887; C:integral to plasma membrane; NAS:UniProtKB.
 GO:0008233; F:peptidase activity; IEA:InterPro.
 GO:0004998; F:transferrin receptor activity; NAS:UniProtKB.
 GO:0006879; P:cellular iron ion homeostasis; TAS:UniProtKB.
 GO:0006826; P:iron ion transport; NAS:UniProtKB.
 GO:0006508; P:proteolysis; IEA:InterPro. 
Interpro
 IPR007484; Peptidase_M28.
 IPR003137; Protease-assoc_domain.
 IPR007365; TFR-like_dimer_dom. 
Pfam
 PF02225; PA
 PF04389; Peptidase_M28
 PF04253; TFR_dimer 
SMART
  
PROSITE
  
PRINTS