CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021059
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 P2Y purinoceptor 12 
Protein Synonyms/Alias
 P2Y12; P2Y12 platelet ADP receptor 
Gene Name
 P2ry12 
Gene Synonyms/Alias
 P2y12 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
330TSGANKKKGQEGGDPubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system (By similarity). 
Sequence Annotation
 MOD_RES 61 61 Phosphoserine.
 MOD_RES 63 63 Phosphoserine.
 CARBOHYD 7 7 N-linked (GlcNAc...) (Potential).
 CARBOHYD 12 12 N-linked (GlcNAc...) (Potential).
 DISULFID 103 181 By similarity.  
Keyword
 Cell membrane; Complete proteome; Direct protein sequencing; Disulfide bond; G-protein coupled receptor; Glycoprotein; Membrane; Phosphoprotein; Receptor; Reference proteome; Transducer; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 343 AA 
Protein Sequence
MEVPGANATS ANTTSIPGTS TLCSRDYKIT QVLFPLLYTV LFFAGLITNS LAMRIFFQIR 60
SKSNFIIFLK NTVISDLLMI LTFPFKILSD AKLGAGHLRT LVCQVTSVTF YFTMYISISF 120
LGLITIDRYL KTTRPFKTSS PSNLLGAKIL SVAIWAFMFL LSLPNMILTN RRPKDKDITK 180
CSFLKSEFGL VWHEIVNYIC QVIFWINFLI VIVCYSLITK ELYRSYVRTR GSAKAPKKRV 240
NIKVFIIIAV FFICFVPFHF ARIPYTLSQT RAVFDCNAEN TLFYVKESTL WLTSLNACLD 300
PFIYFFLCKS FRNSLMSMLR CSTSGANKKK GQEGGDPSEE TPM 343 
Gene Ontology
 GO:0009925; C:basal plasma membrane; IDA:RGD.
 GO:0005901; C:caveola; IDA:RGD.
 GO:0009897; C:external side of plasma membrane; IDA:RGD.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0001621; F:ADP receptor activity; IDA:RGD.
 GO:0001609; F:G-protein coupled adenosine receptor activity; IEA:Compara.
 GO:0001973; P:adenosine receptor signaling pathway; IMP:RGD.
 GO:0007188; P:adenylate cyclase-modulating G-protein coupled receptor signaling pathway; IEA:Compara.
 GO:0070588; P:calcium ion transmembrane transport; IDA:RGD.
 GO:0030030; P:cell projection organization; IMP:RGD.
 GO:0045596; P:negative regulation of cell differentiation; IMP:RGD.
 GO:0010700; P:negative regulation of norepinephrine secretion; IMP:RGD.
 GO:0070527; P:platelet aggregation; IMP:RGD.
 GO:0043270; P:positive regulation of ion transport; IEA:Compara.
 GO:0071805; P:potassium ion transmembrane transport; IDA:RGD.
 GO:0043491; P:protein kinase B signaling cascade; IMP:RGD.
 GO:0051924; P:regulation of calcium ion transport; IMP:RGD. 
Interpro
 IPR000276; GPCR_Rhodpsn.
 IPR017452; GPCR_Rhodpsn_7TM.
 IPR005394; P2Y12_purnocptor.
 IPR002286; purinergic_P2Y_rcpt. 
Pfam
 PF00001; 7tm_1 
SMART
  
PROSITE
 PS00237; G_PROTEIN_RECEP_F1_1
 PS50262; G_PROTEIN_RECEP_F1_2 
PRINTS
 PR00237; GPCRRHODOPSN.
 PR01569; P2Y12PRNCPTR.
 PR01157; P2YPURNOCPTR.