| Tag | Content |
|---|
| CPLM ID | CPLM-011795 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Probable ferric reductase transmembrane component 8 |
Protein Synonyms/Alias | Ferric-chelate reductase 8 |
Gene Name | FRE8 |
Gene Synonyms/Alias | YLR047C; L2114 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 582 | SSVFRQPKIIEPPAQ | ubiquitination | [1] | | 598 | PCLEAAPKKIRIPAG | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Required for the uptake of Fe(3+) ions. May participate in the transport of electrons from cytoplasm to an extracellular substrate (Fe(3+) ion) via FAD and heme intermediates (By similarity). Involved in iron homeostasis. |
Sequence Annotation | DOMAIN 119 666 Ferric oxidoreductase.
NP_BIND 320 326 FAD (Potential).
NP_BIND 442 450 NAD (Potential).
CARBOHYD 371 371 N-linked (GlcNAc...) (Potential).
CARBOHYD 383 383 N-linked (GlcNAc...) (Potential).
CARBOHYD 384 384 N-linked (GlcNAc...) (Potential). |
Keyword | Complete proteome; Electron transport; FAD; Glycoprotein; Ion transport; Iron; Iron transport; Membrane; NAD; Oxidoreductase; Reference proteome; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 686 AA |
Protein Sequence | MNLKSIVSWF KEHLPSFDVD VDKHFRTLRV RKYSQICLLI SFIIICVIIP LMNYLLLTDK 60
FFKICHHLKH HVFNRRSWVH KTHMYHKQSL QLCLICFVFT SFFVIQGANG DLLEITKRMG 120
RISVALMPPL LFLTLRPSPL PHTLYLALLP LHKWISRIVV LESILHTWFY LYYMYINDTL 180
YVKMRKLPNI YGVIALGLFL LIAITSVRYA RRWSYRVFYY VHYVSTWLIL VFLHYHARPG 240
ISYYTTLNVL ILTGQIVYRL HITNVTRVTI VPISSSLSLL EFPLTDLPKK PILPGGHLRI 300
NIYHRNFLRR FFSHLIPFQH PFTIASIPSD NLVRLIIRNG HFPLRTNEKY YITGAFEPEL 360
SFISKPTVPF NITTKSSKNP FRNNSSALIN SPLNFLIKAQ RVFMCVGGSG ISFGLPLLRI 420
LNFNGVNVRL LWVSRDYKDL EVLNHFKNNF EGMEIYISGT EGNEQDIEID YIDYHDCAAD 480
INDEVRSISS SGRVSELGDN SMLSDGNPQP TEPNENTALL SKKSTLRNHH PPKTSDIPDI 540
NADDEIDFTY AFSRSKSRKN TAQGTLTTHS SFNGSSVFRQ PKIIEPPAQD PCLEAAPKKI 600
RIPAGVKVFF GRPTLGDKDY EWCLQTECDA ETDSIQCCRW ANQGRDHAEY LSQVWVLAAG 660
PRGLIESTKR WATDGGLHFH GESFAL 686 |
Gene Ontology | GO:0016021; C:integral to membrane; ISM:SGD. GO:0000293; F:ferric-chelate reductase activity; IEA:EC. GO:0016722; F:oxidoreductase activity, oxidizing metal ions; IMP:SGD. GO:0006875; P:cellular metal ion homeostasis; IMP:SGD. GO:0022900; P:electron transport chain; IEA:UniProtKB-KW. GO:0006811; P:ion transport; IEA:UniProtKB-KW. GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |