[1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J. J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113]
Functional Description
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin- IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons.
Sequence Annotation
REPEAT 82 359 I. REPEAT 469 713 II. REPEAT 1135 1421 III. REPEAT 1458 1711 IV. DOMAIN 1724 1759 EF-hand. NP_BIND 452 459 ATP (Potential). REGION 379 396 Binding to the beta subunit. MOD_RES 746 746 Phosphoserine (By similarity). MOD_RES 784 784 Phosphoserine (By similarity). MOD_RES 1719 1719 Phosphoserine; by PKA (Potential). MOD_RES 2253 2253 Phosphoserine (By similarity). CARBOHYD 256 256 N-linked (GlcNAc...) (Potential). CARBOHYD 1563 1563 N-linked (GlcNAc...) (Potential). CARBOHYD 1675 1675 N-linked (GlcNAc...) (Potential).