UniProt Accession

 EI24_HUMAN; O14681; A8K7D6; Q9BUQ1 

Genbank Protein ID

 AF010313; AK291951; AK315841; CH471065; BC002390 

Genbank Nucleotide ID

 AAC39531.2; BAF84640.1; BAF98732.1; EAW67641.1; AAH02390.1 

Protein Name

 Etoposide-induced protein 2.4 homolog 

Protein Synonyms/Alias

 p53-induced gene 8 protein 

Gene Name

 EI24 

Gene Synonyms/Alias

 PIG8 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
6	**MADSVKTFLQDLA	ubiquitination	[1, 2]
17	QDLARGIKDSIWGIC	ubiquitination	[1]
323	SSSTSAEKFPSPHPS	ubiquitination	[3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 Acts as a negative growth regulator via p53-mediated apoptosis pathway. Regulates formation of degradative autolysosomes during autophagy (By similarity). 

Sequence Annotation

 MOD_RES 56 56 Phosphoserine.
 MOD_RES 318 318 Phosphoserine (By similarity).
 MOD_RES 326 326 Phosphoserine.
 MOD_RES 330 330 Phosphoserine.  

Keyword

 Apoptosis; Autophagy; Complete proteome; Cytoplasm; Disease mutation; Endoplasmic reticulum; Membrane; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 340 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0006914; P:autophagy; IEA:UniProtKB-KW.
 GO:0006917; P:induction of apoptosis; TAS:ProtInc.
 GO:0030308; P:negative regulation of cell growth; IDA:MGI.
 GO:0042493; P:response to drug; IEA:Compara. 

Interpro

 IPR009890; EI24. 

Pfam

  

SMART

  

PROSITE

  

PRINTS