CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038642
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20-specific 
Protein Synonyms/Alias
  
Gene Name
 Nsd1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
1485VTARVHYKKVKKEDLacetylation[1]
1486TARVHYKKVKKEDLTacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Methyltransferase; Nucleus; Reference proteome; Transferase; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2691 AA 
Protein Sequence
MDRTCELSRR NCLLSFSNPV NLDASEDKDS PFGNGQSNFS EPLNGCTMQL PTAASGTSQN 60
AYGQDSPSCY IPLRRLQDLA SMINVEYLSG SADGSESFQD PAKSDSRAQS PIVCTSLSPG 120
GPTALAMKQE PTCNNSPELQ LRVTKTTKNG FLHFENFTGV DDADVDSEMD PEQPVTEDES 180
IEEIFEETQT NATCNYEPKS ENGVEVAMGS EQDSMPESRH GAVERPFLPL APQTEKQKNK 240
QRSEVDGSNE KTALLPAPTS LGDTNVTVEE QFNSINLSFQ DDPDSSPSPL GNMLEIPGTS 300
SPSTSQELPF CQPKKKSTPL KYEVGDLIWA KFKRRPWWPC RICSDPLINT HSKMKVANRR 360
PYREYYVEAF GDPSEKAWVA GKAIVMFEGR HQFEELPVLR KRGKQKEKGY RHKVPQKILS 420
KWEASVGLAE QYDVPKGSKN QKCVSSSVKL DSEEDMPFED CTNDPDSEHL LLNGCLKSLA 480
FDSEHSADEK EKPCAKSRVR KSSDNIKRTS VKKDLVPFES RKEERRGKIP DNLGLDFISG 540
GVSDKQASNE LSRIANSLTG SSTAPGSFLF SSSVQNTAKT DFETPDCDSL SGLSESALIS 600
KHSGEKKKLQ PGQVCSSKVQ LCYVGAGDEE KRSNSVSVST TSDDGCSDLD PTEHNSGFQN 660
SVLGITDAFD KTENALSVHK NETQYSRYPV TNRIKEKQKS LITNSHADHL MGSTKTMEPE 720
TAELSQVNLS DLKISSPIPK PQPEFRNDGL TTKFSAPPGI RNENPLTKGG LANQTLLPLK 780
CRQPKFRSIK CKHKESPAVA ETSATSEDLS LKCCSSDTNG SPLANISKSG KGEGLKLLNN 840
MHEKTRDSSD IETAVVKHVL SELKELSYRS LSEDVSDSGT AKASKPLLFS SASSQNHIPI 900
EPDYKFSTLL MMLKDMHDSK TKEQRLMTAQ NLASYRTPDR GDCSSGSPVG TSKVLVLGSS 960
TPNSEKPGDS TQDSVHQSPG GGDSALSGEL SSSLSSLASD KRELPACGKI RSNCIPRRNC 1020
GRAKPSSKLR ETISAQMVKP SVNPKALKTE RKRKFSRLPA VTLAANRLGN KESGSVNGPS 1080
RGGAEDPGKE EPLQQMDLLR NEDTHFSDVH FDSKAKQSDP DKNLEKEPSF ENRKGPELGS 1140
EMNTENDELH GVNQVVPKKR WQRLNQRRPK PGKRANRFRE KENSEGAFGV LLPADAVQKA 1200
REDYLEQRAP PTSKPEDSAA DPNHGSHSES VAPRLNVCEK SSVGMGDVEK ETGIPSLMPQ 1260
TKLPEPAIRS EKKRLRKPSK WLLEYTEEYD QIFAPKKKQK KVQEQVHKVS SRCEDESLLA 1320
RCQPSAQNKQ VDENSLISTK EEPPVLEREA PFLEGPLAQS DLGVTHAELP QLTLSVPVAP 1380
EASPRPALES EELLVKTPGN YESKRQRKPT KKLLESNDLD PGFMPKKGDL GLSRKCFEAS 1440
RSGNGIVESR ATSHLKEFSG GTTKIFDKPR KRKRQRLVTA RVHYKKVKKE DLTKDTPSSE 1500
GELLIHRTAA SPKEILEEGV EHDPGMSASK KLQVERGGGA ALKENVCQNC EKLGELLLCE 1560
AQCCGAFHLE CLGLPEMPRG KFICNECHTG IHTCFVCKQS GEDVKRCLLP LCGKFYHEEC 1620
VQKYPPTVTQ NKGFRCPLHI CITCHAANPA NVSASKGRLM RCVRCPVAYH ANDFCLAAGS 1680
KILASNSIIC PNHFTPRRGC RNHEHVNVSW CFVCSEGGSL LCCDSCPAAF HRECLNIDIP 1740
EGNWYCNDCK AGKKPHYREI VWVKVGRYRW WPAEICHPRA VPSNIDKMRH DVGEFPVLFF 1800
GSNDYLWTHQ ARVFPYMEGD VSSKDKMGKG VDGTYKKALQ EAAARFEELK AQKELRQLQE 1860
DRKNDKKPPP YKHIKVNRPI GRVQIFTADL SEIPRCNCKA TDENPCGIDS ECINRMLLYE 1920
CHPTVCPAGV RCQNQCFSKR QYPDVEIFRT LQRGWGLRTK TDIKKGEFVN EYVGELIDEE 1980
ECRARIRYAQ EHDITNFYML TLDKDRIIDA GPKGNYARFM NHCCQPNCET QKWSVNGDTR 2040
VGLFALSDIK AGTELTFNYN LECLGNGKTV CKCGAPNCSG FLGVRPKNQP IVTEEKSRKF 2100
KRKPHGKRRS QGEVTKERED ECFSCGDAGQ LVSCKKPGCP KVYHADCLNL TKRPAGKWEC 2160
PWHQCDVCGK EAASFCEMCP SSFCKQHREG MLFISKLDGR LSCTEHDPCG PNPLEPGEIR 2220
EYVPPTATSP PSPGTQPKEQ SSEMATQGPK KSDQPPTDAT QLLPLSKKAL TGSCQRPLLP 2280
ERPPERTDSS SHLLDRIRDL AGSGTKSQSL VSSQRPQDRP PAKEGPRPQP PDRASPMTRP 2340
SSSPSVSSLP LERPLRMTDS RLDKSIGAAS PKSQAVEKTP ASTGLRLSSP DRLLTTNSPK 2400
PQISDRPPEK SHASLTQRLP PPEKVLSAVV QSLVAKEKAL RPVDQNTQSK HRPAVVMDLI 2460
DLTPRQKERA ASPQEVTPQA DEKTAMLESS SWPSSKGLGH IPRATEKISV SESLQPSGKV 2520
AAPSEHPWQA VKSLTHARFL SPPSAKAFLY ESATQASGRT PVGAEQTPGP PSPAPGLVKQ 2580
VKQLSRGLTA KSGQSFRSLG KISASLPNEE KKLTTTEQSP WGLGKASPGA GLWPIVAGQT 2640
LAQACWSAGG TQTLAQTCWS LGRGQDPKPE NAIQALNQAP SSRKCADSEK K 2691 
Gene Ontology
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0003682; F:chromatin binding; IDA:MGI.
 GO:0042054; F:histone methyltransferase activity; IDA:MGI.
 GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:InterPro.
 GO:0003712; F:transcription cofactor activity; IDA:MGI.
 GO:0008270; F:zinc ion binding; IEA:Compara.
 GO:0001702; P:gastrulation with mouth forming second; IMP:MGI.
 GO:0034968; P:histone lysine methylation; IEA:GOC.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0006355; P:regulation of transcription, DNA-dependent; TAS:MGI. 
Interpro
 IPR006560; AWS.
 IPR003616; Post-SET_dom.
 IPR000313; PWWP.
 IPR001214; SET_dom.
 IPR019786; Zinc_finger_PHD-type_CS.
 IPR011011; Znf_FYVE_PHD.
 IPR001965; Znf_PHD.
 IPR019787; Znf_PHD-finger.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF00628; PHD
 PF00855; PWWP
 PF00856; SET 
SMART
 SM00570; AWS
 SM00249; PHD
 SM00508; PostSET
 SM00293; PWWP
 SM00184; RING
 SM00317; SET 
PROSITE
 PS51215; AWS
 PS50868; POST_SET
 PS50812; PWWP
 PS50280; SET
 PS01359; ZF_PHD_1
 PS50016; ZF_PHD_2
 PS50089; ZF_RING_2 
PRINTS