| Tag | Content |
|---|
| CPLM ID | CPLM-003437 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Acriflavine resistance protein A |
Protein Synonyms/Alias | |
Gene Name | acrA |
Gene Synonyms/Alias | lir; mtcA; b0463; JW0452 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 175 | RINLAYTKVTSPISG | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | AcrAB is a drug efflux protein with a broad substrate specificity. |
Sequence Annotation | LIPID 25 25 N-palmitoyl cysteine (Potential).
LIPID 25 25 S-diacylglycerol cysteine (Potential). |
Keyword | 3D-structure; Antibiotic resistance; Cell inner membrane; Cell membrane; Complete proteome; Lipoprotein; Membrane; Palmitate; Reference proteome; Signal; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 397 AA |
Protein Sequence | MNKNRGFTPL AVVLMLSGSL ALTGCDDKQA QQGGQQMPAV GVVTVKTEPL QITTELPGRT 60
SAYRIAEVRP QVSGIILKRN FKEGSDIEAG VSLYQIDPAT YQATYDSAKG DLAKAQAAAN 120
IAQLTVNRYQ KLLGTQYISK QEYDQALADA QQANAAVTAA KAAVETARIN LAYTKVTSPI 180
SGRIGKSNVT EGALVQNGQA TALATVQQLD PIYVDVTQSS NDFLRLKQEL ANGTLKQENG 240
KAKVSLITSD GIKFPQDGTL EFSDVTVDQT TGSITLRAIF PNPDHTLLPG MFVRARLEEG 300
LNPNAILVPQ QGVTRTPRGD ATVLVVGADD KVETRPIVAS QAIGDKWLVT EGLKAGDRVV 360
ISGLQKVRPG VQVKAQEVTA DNNQQAASGA QPEQSKS 397 |
Gene Ontology | GO:0005886; C:plasma membrane; IDA:EcoCyc. GO:0015238; F:drug transmembrane transporter activity; IMP:EcoliWiki. GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW. |
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