UniProt Accession

 SKP_ECOLI; P0AEU7; P11457 

Genbank Protein ID

 M21118; X75465; U70214; U00096; AP009048; X54797 

Genbank Nucleotide ID

 AAA24630.1; CAA53207.1; AAB08607.1; AAC73289.1; BAA77853.1; CAA38567.1 

Protein Name

 Chaperone protein Skp 

Protein Synonyms/Alias

 DNA-binding 17 kDa protein; Histone-like protein HLP-1; Seventeen kilodalton protein 

Gene Name

 skp 

Gene Synonyms/Alias

 hlpA; ompH; b0178; JW0173 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
51	NTLENEFKGRASELQ	acetylation	[1]
67	METDLQAKMKKLQSM	acetylation	[1]
85	SDRTKLEKDVMAQRQ	acetylation	[1]
97	QRQTFAQKAQAFEQD	acetylation	[1]
158	DITADVLKQVK****	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm. Required for the efficient release of OmpA from the inner membrane, the maintenance of its solubility in the periplasm, and, in association with lipopolysaccharide (LPS), for the efficient folding and insertion of OmpA into the outer membrane. 

Sequence Annotation

 REGION 97 108 Lipopolysaccharide binding (Potential).  

Keyword

 3D-structure; Chaperone; Complete proteome; Direct protein sequencing; Periplasm; Reference proteome; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 161 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0030288; C:outer membrane-bounded periplasmic space; IDA:EcoliWiki.
 GO:0001530; F:lipopolysaccharide binding; IPI:EcoCyc.
 GO:0051085; P:chaperone mediated protein folding requiring cofactor; IGI:EcoCyc.
 GO:0043165; P:Gram-negative-bacterium-type cell outer membrane assembly; IDA:EcoCyc.
 GO:0065002; P:intracellular protein transmembrane transport; IMP:EcoCyc.
 GO:0032978; P:protein insertion into membrane from inner side; IMP:EcoCyc.
 GO:0050821; P:protein stabilization; IDA:EcoCyc. 

Interpro

 IPR005632; Chaperone_Skp.
 IPR024930; Skp_domain. 

Pfam

 PF03938; OmpH 

SMART

 SM00935; OmpH 

PROSITE

  

PRINTS