| Tag | Content |
|---|
| CPLM ID | CPLM-023665 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Angiomotin-like protein 2 |
Protein Synonyms/Alias | Leman coiled-coil protein; LCCP |
Gene Name | AMOTL2 |
Gene Synonyms/Alias | KIAA0989 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 341 | ELESSAEKAGRIEKL | ubiquitination | [1] | | 408 | ANRRLASKTQEAQAG | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC. |
Sequence Annotation | MOTIF 776 779 PDZ-binding.
MOD_RES 107 107 Phosphotyrosine; by FGFR1 (By |
Keyword | Alternative splicing; Coiled coil; Complete proteome; Endosome; Phosphoprotein; Polymorphism; Reference proteome; Wnt signaling pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 779 AA |
Protein Sequence | MRTLEDSSGT VLHRLIQEQL RYGNLTETRT LLAIQQQALR GGAGTGGTGS PQASLEILAP 60
EDSQVLQQAT RQEPQGQEHQ GGENHLAENT LYRLCPQPSK GEELPTYEEA KAHSQYYAAQ 120
QAGTRPHAGD RDPRGAPGGS RRQDEALREL RHGHVRSLSE RLLQLSLERN GARAPSHMSS 180
SHSFPQLARN QQGPPLRGPP AEGPESRGPP PQYPHVVLAH ETTTAVTDPR YRARGSPHFQ 240
HAEVRILQAQ VPPVFLQQQQ QYQYLQQSQE HPPPPHPAAL GHGPLSSLSP PAVEGPVSAQ 300
ASSATSGSAH LAQMEAVLRE NARLQRDNER LQRELESSAE KAGRIEKLES EIQRLSEAHE 360
SLTRASSKRE ALEKTMRNKM DSEMRRLQDF NRDLRERLES ANRRLASKTQ EAQAGSQDMV 420
AKLLAQSYEQ QQEQEKLERE MALLRGAIED QRRRAELLEQ ALGNAQGRAA RAEEELRKKQ 480
AYVEKVERLQ QALGQLQAAC EKREQLELRL RTRLEQELKA LRAQQRQAGA PGGSSGSGGS 540
PELSALRLSE QLREKEEQIL ALEADMTKWE QKYLEERAMR QFAMDAAATA AAQRDTTLIR 600
HSPQPSPSSS FNEGLLTGGH RHQEMESRLK VLHAQILEKD AVIKVLQQRS RRDPGKAIQG 660
SLRPAKSVPS VFAAAAAGTQ GWQGLSSSER QTADAPARLT TADRAPTEEP VVTAPPAAHA 720
KHGSRDGSTQ TEGPPDSTST CLPPEPDSLL GCSSSQRAAS LDSVATSRVQ DLSDMVEILI 780 |
Gene Ontology | GO:0016324; C:apical plasma membrane; IEA:Compara. GO:0031410; C:cytoplasmic vesicle; IEA:Compara. GO:0005829; C:cytosol; TAS:Reactome. GO:0055037; C:recycling endosome; IEA:UniProtKB-SubCell. GO:0005923; C:tight junction; IEA:Compara. GO:0035329; P:hippo signaling cascade; TAS:Reactome. GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. |
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