| Tag | Content |
|---|
| CPLM ID | CPLM-007812 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Alpha-internexin |
Protein Synonyms/Alias | Alpha-Inx; 66 kDa neurofilament protein; NF-66; Neurofilament-66 |
Gene Name | Ina |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 95 | KIIRTNEKEQLQGLN | ubiquitination | [1] | | 216 | ARLDLEKKVESLLDE | ubiquitination | [1] | | 288 | QSAEEWYKSKFANLN | ubiquitination | [1] | | 290 | AEEWYKSKFANLNEQ | ubiquitination | [1] | | 438 | ILSSTASKVSSAGLS | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NF-L to form the filamentous backbone to which NF-M and NF-H attach to form the cross-bridges (By similarity). |
Sequence Annotation | REGION 1 87 Head.
REGION 88 408 Rod.
REGION 88 129 Coil 1A.
REGION 130 142 Linker 1.
REGION 143 238 Coil 1B.
REGION 239 262 Linker 2.
REGION 263 408 Coil 2.
REGION 409 504 Tail.
MOD_RES 72 72 Phosphoserine.
MOD_RES 290 290 N6-acetyllysine (By similarity).
MOD_RES 335 335 Phosphoserine.
MOD_RES 501 501 Phosphoserine (By similarity). |
Keyword | Acetylation; Coiled coil; Complete proteome; Developmental protein; Differentiation; Direct protein sequencing; Glycoprotein; Intermediate filament; Neurogenesis; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 504 AA |
Protein Sequence | MSFGSEHYLC SASSYRKVFG DSSRLSARLS GPGGSGSFRS QSLSRSNVAS TAACSSASSL 60
GLGLAYRRLP ASDGLDLSQA AARTNEYKII RTNEKEQLQG LNDRFAVFIE KVHQLETQNR 120
ALEAELAALR QRHAEPSRVG ELFQRELREL RAQLEEASSA RAQALLERDG LAEEVQRLRA 180
RCEEESRGRE GAERALKAQQ RDVDGATLAR LDLEKKVESL LDELAFVRQV HDEEVAELLA 240
TLQASSQAAA EVDVAVAKPD LTSALREIRA QYESLAAKNL QSAEEWYKSK FANLNEQAAR 300
STEAIRASRE EIHEYRRQLQ ARTIEIEGLR GANESLERQI LELEERHSAE VAGYQDSIGQ 360
LESDLRNTKS EMARHLREYQ DLLNVKMALD IEIAAYRKLL EGEETRFSTG GLSISGLNPL 420
PNPSYLLPPR ILSSTASKVS SAGLSLKKED EEEEEEEEDA SKEVSKKTSK VGEGFEETLG 480
EAVISTKKTG KSATEESTSS SQKM 504 |
Gene Ontology | GO:0005883; C:neurofilament; IDA:MGI. GO:0005198; F:structural molecule activity; IEA:InterPro. GO:0030154; P:cell differentiation; IEA:UniProtKB-KW. GO:0007399; P:nervous system development; IEA:UniProtKB-KW. GO:0060052; P:neurofilament cytoskeleton organization; IGI:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |