UniProt Accession

 GHC1_HUMAN; Q9H936; A8K366; C9J1H6; E9PJD3; E9PKB2; E9PL68; E9PN26; E9PNQ3; E9PP01; E9PR97; Q8TBU8 

Genbank Protein ID

 AJ428202; AK023106; AK290481; AP006621; BC019033; BC023545; BC024212 

Genbank Nucleotide ID

 CAD21007.1; BAB14407.1; BAF83170.1; AAH19033.1; AAH23545.1; AAH24212.2 

Protein Name

 Mitochondrial glutamate carrier 1 

Protein Synonyms/Alias

 GC-1; Glutamate/H(+) symporter 1; Solute carrier family 25 member 22 

Gene Name

 SLC25A22 

Gene Synonyms/Alias

 GC1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
55	SMSDCLIKTVRSEGY	ubiquitination	[1, 2]
83	VTPEKAIKLAANDFF	ubiquitination	[1, 2]
96	FFRHQLSKDGQKLTL	ubiquitination	[1, 2]
100	QLSKDGQKLTLLKEM	ubiquitination	[1, 2]
142	GRIAAQRKILAAQGQ	ubiquitination	[1, 2]
188	RGIAGLYKGLGATLL	ubiquitination	[1, 2]
286	EGPSAFLKGAYCRAL	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Involved in the transport of glutamate across the inner mitochondrial membrane. Glutamate is cotransported with H(+). 

Sequence Annotation

 REPEAT 6 93 Solcar 1.
 REPEAT 101 214 Solcar 2.
 REPEAT 223 312 Solcar 3.  

Keyword

 Complete proteome; Disease mutation; Epilepsy; Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome; Repeat; Symport; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 323 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005743; C:mitochondrial inner membrane; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0005313; F:L-glutamate transmembrane transporter activity; IDA:UniProtKB.
 GO:0015293; F:symporter activity; IEA:UniProtKB-KW. 

Interpro

 IPR002067; Mit_carrier.
 IPR018108; Mitochondrial_sb/sol_carrier.
 IPR023395; Mt_carrier_dom. 

Pfam

 PF00153; Mito_carr 

SMART

  

PROSITE

 PS50920; SOLCAR 

PRINTS

 PR00926; MITOCARRIER.