UniProt Accession

 NEUR1_HUMAN; Q99519 

Genbank Protein ID

 AF040958; X78687; U84246; AF134726; BA000025; BT007206; BC000722; BC011900 

Genbank Nucleotide ID

 AAB96774.1; CAA55356.1; AAD09239.1; AAD21814.1; BAB63297.1; AAP35870.1; AAH00722.1; AAH11900.1 

Protein Name

 Sialidase-1 

Protein Synonyms/Alias

 Acetylneuraminyl hydrolase; G9 sialidase; Lysosomal sialidase; N-acetyl-alpha-neuraminidase 1 

Gene Name

 NEU1 

Gene Synonyms/Alias

 NANH 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
107	SSSDEGAKFIALRRS	ubiquitination	[1]
206	GPGSGIQKQREPRKG	ubiquitination	[2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Catalyzes the removal of sialic acid (N-acetylneuramic acid) moities from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage. 

Sequence Annotation

 REPEAT 112 123 BNR 1.
 REPEAT 172 183 BNR 2.
 REPEAT 231 242 BNR 3.
 REPEAT 347 358 BNR 4.
 MOTIF 77 80 FRIP motif.
 MOTIF 412 415 Internalization signal.
 ACT_SITE 103 103 Proton acceptor (By similarity).
 ACT_SITE 370 370 Nucleophile (By similarity).
 ACT_SITE 394 394 Potential.
 BINDING 78 78 Substrate (By similarity).
 BINDING 280 280 Substrate (By similarity).
 BINDING 341 341 Substrate (By similarity).
 CARBOHYD 186 186 N-linked (GlcNAc...) (Potential).
 CARBOHYD 343 343 N-linked (GlcNAc...) (Potential).
 CARBOHYD 352 352 N-linked (GlcNAc...).  

Keyword

 Cell membrane; Complete proteome; Cytoplasmic vesicle; Direct protein sequencing; Disease mutation; Glycoprotein; Glycosidase; Hydrolase; Lysosome; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 415 AA 

Protein Sequence

Gene Ontology

 GO:0030054; C:cell junction; IDA:HPA.
 GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.
 GO:0043202; C:lysosomal lumen; TAS:Reactome.
 GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0052794; F:exo-alpha-(2->3)-sialidase activity; IEA:EC.
 GO:0052795; F:exo-alpha-(2->6)-sialidase activity; IEA:EC.
 GO:0052796; F:exo-alpha-(2->8)-sialidase activity; IEA:EC.
 GO:0004308; F:exo-alpha-sialidase activity; TAS:ProtInc.
 GO:0006687; P:glycosphingolipid metabolic process; TAS:Reactome.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 

Interpro

 IPR026942; Sialidase-1.
 IPR026856; Sialidase_fam.
 IPR011040; Sialidases. 

Pfam

  

SMART

  

PROSITE

  

PRINTS