CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028428
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Sodium/hydrogen exchanger 8 
Protein Synonyms/Alias
  
Gene Name
 Slc9a8 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
520HHGRIQMKSLTNKWYubiquitination[1]
525QMKSLTNKWYEEVRQubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Ion transport; Membrane; Reference proteome; Sodium; Sodium transport; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 545 AA 
Protein Sequence
MAEEEFSNTT HETFNFTLHT TLGVTTKLVL PTPAKPILPV QTGEQAQQEE QSSGMTIFFS 60
LLVLGILMGA VIKVIEFKKL ANWKEEEMFR PNMFFLLLLP PIIFESGYSL HKGNFFQNIG 120
SITLFAVFGT AISAFVVGGG IYFLGQADVI SKLNMTDSFA FGSLISAVDP VATIAIFNAL 180
HVDPVLNMLV FGESILNDAV SIVLTNTAEG LTRKHMSDVS GWQTFSQALG YFLKMFFGSA 240
ALGTLTGLIS ALIDLRKTPS LEFGMMIIFA YLPYGLAEGI SLSGIMAILF SGIVMSHYTH 300
HNLSPVTQIL MQQTLRTVAF LCETCVFAFL GLSIFSFPHK FEISFVIWCI VLVLFGRAVN 360
IFPLSYLLNF FRDHKITPKM MFIMWFSGLR GAIPYALSLH LGLEPMEKRQ LIGTTTIVIV 420
LFTILLLGGS TMPLIRLVDI EDARARRRSK KDVNLSKTEK MGNAIESEHL SELTEEEYEA 480
HYIRQQDLKG FMWLDAKYLN PFFTRRLTQE DLHHGRIQMK SLTNKWYEEV RQGPSGSEDD 540
EQELF 545 
Gene Ontology
 GO:0005794; C:Golgi apparatus; IDA:MGI.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0015386; F:potassium:hydrogen antiporter activity; IDA:MGI.
 GO:0015385; F:sodium:hydrogen antiporter activity; IDA:MGI.
 GO:0051453; P:regulation of intracellular pH; IDA:MGI. 
Interpro
 IPR006153; Cation/H_exchanger.
 IPR018422; Cation/H_exchanger_CPA1.
 IPR018409; Na/H_exchanger_8_eu.
 IPR004709; NaH_exchanger. 
Pfam
 PF00999; Na_H_Exchanger 
SMART
  
PROSITE
  
PRINTS
 PR01084; NAHEXCHNGR.