CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010573
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 D-2-hydroxyglutarate dehydrogenase, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 D2hgdh 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
115RTVRGCSKVLLRPQTacetylation[1]
510SKPPVAVKLMQQLKAacetylation[1]
522LKAMLDPKGILNPYKacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Catalyzes the oxidation of D-2-hydroxyglutarate to alpha-ketoglutarate (By similarity). 
Sequence Annotation
 DOMAIN 110 289 FAD-binding PCMH-type.  
Keyword
 Complete proteome; FAD; Flavoprotein; Mitochondrion; Oxidoreductase; Reference proteome; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 535 AA 
Protein Sequence
MVLHLVPRWS ASLFRASPRW KKTYSQRASA QLKWLGCPRS VYSPLACRAY SKVSGSPEVM 60
LTPERYPVQR LPFSTVSEED LAAFECIIPG RVITDPEQLQ TCNVDWLRTV RGCSKVLLRP 120
QTSEEVSQIL RHCYKRNLAV NPQGGNTGMV GGSVPVFDEV ILSTALMNQV ISFHDVSGIL 180
VCQAGCVLEE LSRYVQERDF IMPLDLGAKG SCHIGGNVAT NAGGLRFLRY GSLRGTVLGL 240
EVVLADGTIL NCLTSLRKDN TGYDLKQMFI GSEGTLGVIT AVSIVCPPRP KAVNVAFLGC 300
PGFTEVLQTF RTCKGQLGEI LSAFEFMDAE CMQLVGQHLH LTNPVQESPF YVLVETSGSS 360
AGHDAEKLTN VLEQVLNSGL VIDGTMATDQ RKVQMLWALR ERITEALSRD GYVFKYDLSL 420
PVERLYDLVI DLRTRLGPRA KHVVGYGHLG DGNLHLNVTA EAFSQELLGA LEPYVYAWTA 480
EQRGSVSAEH GLGFKKKNVL GYSKPPVAVK LMQQLKAMLD PKGILNPYKT LPARA 535 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:HGNC.
 GO:0051990; F:(R)-2-hydroxyglutarate dehydrogenase activity; IDA:HGNC.
 GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
 GO:0008762; F:UDP-N-acetylmuramate dehydrogenase activity; IEA:InterPro.
 GO:0044267; P:cellular protein metabolic process; IDA:HGNC.
 GO:0032025; P:response to cobalt ion; IDA:HGNC.
 GO:0010042; P:response to manganese ion; IDA:HGNC.
 GO:0010043; P:response to zinc ion; IDA:HGNC. 
Interpro
 IPR016169; CO_DH_flavot_FAD-bd_sub2.
 IPR016166; FAD-bd_2.
 IPR016167; FAD-bd_2_sub1.
 IPR016164; FAD-linked_Oxase-like_C.
 IPR004113; FAD-linked_oxidase_C.
 IPR006094; Oxid_FAD_bind_N.
 IPR016171; Vanillyl_alc_oxidase_C-sub2. 
Pfam
 PF02913; FAD-oxidase_C
 PF01565; FAD_binding_4 
SMART
  
PROSITE
 PS51387; FAD_PCMH 
PRINTS