UniProt Accession

 ISG20_HUMAN; Q96AZ6; O00441; O00586 

Genbank Protein ID

 X89773; U88964; BT006952; CR456942; BC007922; BC016341 

Genbank Nucleotide ID

 CAA61915.2; AAB53416.1; AAP35598.1; CAG33223.1; AAH07922.1; AAH16341.1 

Protein Name

 Interferon-stimulated gene 20 kDa protein 

Protein Synonyms/Alias

 Estrogen-regulated transcript 45 protein; Promyelocytic leukemia nuclear body-associated protein ISG20 

Gene Name

 ISG20 

Gene Synonyms/Alias

 HEM45 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
82	LEILQLLKGKLVVGH	ubiquitination	[1]

Reference

 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

 Exonuclease with specificity for single-stranded RNA and, to a lesser extent for DNA. Degrades RNA at a rate that is approximately 35-fold higher than its rate for single-stranded DNA. Involved in the antiviral function of IFN against RNA viruses. 

Sequence Annotation

 METAL 11 11 Manganese 1.
 METAL 13 13 Manganese 1.
 METAL 90 90 Manganese 2.
 METAL 93 93 Manganese 2.
 METAL 154 154 Manganese 1.  

Keyword

 3D-structure; Alternative splicing; Antiviral defense; Complete proteome; Exonuclease; Hydrolase; Immunity; Innate immunity; Manganese; Metal-binding; Nuclease; Nucleus; Reference proteome; RNA-binding; rRNA processing. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 181 AA 

Protein Sequence

Gene Ontology

 GO:0016605; C:PML body; IDA:UniProtKB.
 GO:0000175; F:3'-5'-exoribonuclease activity; IDA:UniProtKB.
 GO:0008859; F:exoribonuclease II activity; IEA:EC.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0008310; F:single-stranded DNA specific 3'-5' exodeoxyribonuclease activity; IDA:UniProtKB.
 GO:0008283; P:cell proliferation; TAS:ProtInc.
 GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
 GO:0000738; P:DNA catabolic process, exonucleolytic; IDA:UniProtKB.
 GO:0009615; P:response to virus; IDA:UniProtKB.
 GO:0006401; P:RNA catabolic process; IDA:UniProtKB.
 GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
 GO:0060337; P:type I interferon-mediated signaling pathway; TAS:Reactome. 

Interpro

 IPR006055; Exonuclease.
 IPR013520; Exonuclease_RNaseT/DNA_pol3.
 IPR012337; RNaseH-like_dom. 

Pfam

 PF00929; RNase_T 

SMART

 SM00479; EXOIII 

PROSITE

  

PRINTS