UniProt Accession

 NSUN3_HUMAN; Q9H649; Q6PG41; Q8IXG9; Q9H6M2 

Genbank Protein ID

 AK025762; AK026262; AF169972; BC020602; BC057238; AF351612 

Genbank Nucleotide ID

 BAB15234.1; BAB15417.1; AAQ13600.1; AAH20602.1; AAH57238.1; AAN76512.1 

Protein Name

 Putative methyltransferase NSUN3 

Protein Synonyms/Alias

 NOL1/NOP2/Sun domain family member 3 

Gene Name

 NSUN3 

Gene Synonyms/Alias

 MSTP077; UG0651E06 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
67	NYPFELEKDLHLKGY	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 May have S-adenosyl-L-methionine-dependent methyl- transferase activity (Potential). 

Sequence Annotation

 REGION 139 145 S-adenosyl-L-methionine binding (By
 ACT_SITE 265 265 Nucleophile (Potential).
 BINDING 162 162 S-adenosyl-L-methionine (By similarity).
 BINDING 193 193 S-adenosyl-L-methionine (By similarity).
 BINDING 211 211 S-adenosyl-L-methionine (By similarity).  

Keyword

 Complete proteome; Methyltransferase; Polymorphism; Reference proteome; S-adenosyl-L-methionine; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 340 AA 

Protein Sequence

Gene Ontology

 GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW. 

Interpro

 IPR001678; Fmu/NOL1/Nop2p.
 IPR023267; RCMT. 

Pfam

 PF01189; Nol1_Nop2_Fmu 

SMART

  

PROSITE

 PS01153; NOL1_NOP2_SUN 

PRINTS

 PR02008; RCMTFAMILY.