CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006098
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Uroporphyrinogen decarboxylase 
Protein Synonyms/Alias
 UPD; URO-D 
Gene Name
 HEM12 
Gene Synonyms/Alias
 HEM6; POP3; YDR047W; YD9609.03 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
43LPEYHEVKNNRDFFQacetylation[1]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 
Functional Description
 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity). 
Sequence Annotation
 REGION 30 34 Substrate binding (By similarity).
 BINDING 48 48 Substrate (By similarity).
 BINDING 80 80 Substrate (By similarity).
 BINDING 81 81 Substrate (By similarity).
 BINDING 160 160 Substrate (By similarity).
 BINDING 215 215 Substrate (By similarity).
 BINDING 338 338 Substrate (By similarity).  
Keyword
 Complete proteome; Cytoplasm; Decarboxylase; Heme biosynthesis; Lyase; Nucleus; Porphyrin biosynthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 362 AA 
Protein Sequence
MGNFPAPKND LILRAAKGEK VERPPCWIMR QAGRYLPEYH EVKNNRDFFQ TCRDAEIASE 60
ITIQPVRRYR GLIDAAIIFS DILVIPQAMG MRVEMLEGKG PHFPEPLRNP EDLQTVLDYK 120
VDVLKELDWA FKAITMTRIK LDGEVPLFGF CGGPWTLMVY MTEGGGSRLF RFAKQWINMY 180
PELSHKLLQK ITDVAVEFLS QQVVAGAQIL QVFESWGGEL SSVDFDEFSL PYLRQIAERV 240
PKRLQELGIM EQIPMIVFAK GSWYALDKLC CSGFDVVSLD WSWDPREAVK INKNRVTLQG 300
NLDPGVMYGS KEVITKKVKQ MIEAFGGGKS RYIVNFGHGT HPFMDPDVIK FFLEECHRIG 360
SK 362 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0004853; F:uroporphyrinogen decarboxylase activity; IDA:SGD.
 GO:0006783; P:heme biosynthetic process; IMP:SGD.
 GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway. 
Interpro
 IPR006361; Uroporphyrinogen_deCO2ase_HemE.
 IPR000257; Uroporphyrinogen_deCOase. 
Pfam
 PF01208; URO-D 
SMART
  
PROSITE
 PS00906; UROD_1
 PS00907; UROD_2 
PRINTS