CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001578
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 6-phosphogluconolactonase 
Protein Synonyms/Alias
 6PGL 
Gene Name
 PGLS 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
128EAAEDYAKKLRQAFQubiquitination[1, 2]
180APISDSPKPPPQRVTacetylation[3]
254LLTVPFEKHSTL***ubiquitination[4]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate. 
Sequence Annotation
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 180 180 N6-acetyllysine.  
Keyword
 Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Hydrolase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 258 AA 
Protein Sequence
MAAPAPGLIS VFSSSQELGA ALAQLVAQRA ACCLAGARAR FALGLSGGSL VSMLARELPA 60
AVAPAGPASL ARWTLGFCDE RLVPFDHAES TYGLYRTHLL SRLPIPESQV ITINPELPVE 120
EAAEDYAKKL RQAFQGDSIP VFDLLILGVG PDGHTCSLFP DHPLLQEREK IVAPISDSPK 180
PPPQRVTLTL PVLNAARTVI FVATGEGKAA VLKRILEDQE ENPLPAALVQ PHTGKLCWFL 240
DEAAARLLTV PFEKHSTL 258 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0017057; F:6-phosphogluconolactonase activity; IDA:UniProtKB.
 GO:0048029; F:monosaccharide binding; IEA:Compara.
 GO:0006098; P:pentose-phosphate shunt; IDA:UniProtKB.
 GO:0009051; P:pentose-phosphate shunt, oxidative branch; IEA:Compara. 
Interpro
 IPR005900; 6-phosphogluconolactonase_DevB.
 IPR006148; Glc/Gal-6P_isomerase. 
Pfam
 PF01182; Glucosamine_iso 
SMART
  
PROSITE
  
PRINTS