UniProt Accession

 PFD4_HUMAN; Q9NQP4; Q5TD11; Q92779 

Genbank Protein ID

 U41816; AL133335; BC010953 

Genbank Nucleotide ID

 AAB17063.1; CAI19316.1; AAH10953.1 

Protein Name

 Prefoldin subunit 4 

Protein Synonyms/Alias

 Protein C-1 

Gene Name

 PFDN4 

Gene Synonyms/Alias

 PFD4 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
7	*MAATMKKAAAEDVN	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. 

Sequence Annotation

 MOD_RES 125 125 Phosphoserine.  

Keyword

 Chaperone; Complete proteome; Cytoplasm; Mitochondrion; Nucleus; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 134 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; NAS:UniProtKB.
 GO:0005739; C:mitochondrion; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0016272; C:prefoldin complex; IEA:InterPro.
 GO:0051087; F:chaperone binding; TAS:UniProtKB.
 GO:0051084; P:'de novo' posttranslational protein folding; TAS:Reactome. 

Interpro

 IPR002777; PFD_beta-like.
 IPR016661; PFDN4.
 IPR009053; Prefoldin. 

Pfam

 PF01920; Prefoldin_2 

SMART

  

PROSITE

  

PRINTS