Tag | Content |
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CPLM ID | CPLM-043428 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 |
Protein Synonyms/Alias | |
Gene Name | MACF1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
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587 | LKAEPLTKATHSSST | ubiquitination | [1] | 844 | LQDSIKRKYSCDHNT | ubiquitination | [1] | 1677 | SVVEAIEKRIISETV | ubiquitination | [1] | 1734 | ESYLRTSKNLIDPNT | ubiquitination | [1] | 1744 | IDPNTAEKIGLLDLM | ubiquitination | [1] | 1763 | VHQESGFKLLPVKQL | ubiquitination | [1] | 1768 | GFKLLPVKQLAGGMV | ubiquitination | [1] | 1778 | AGGMVSLKSGRKVSI | ubiquitination | [1] | 1782 | VSLKSGRKVSIFRAV | ubiquitination | [1] | 1938 | TTEILSWKKAIESGI | ubiquitination | [1] | 1939 | TEILSWKKAIESGIL | ubiquitination | [1] | 1991 | PCSKSHPKATASQSE | ubiquitination | [1] | 2023 | QRLLLLDKELMETLT | ubiquitination | [1] | 2041 | EYQTSPPKVVEIGHQ | ubiquitination | [1] | 2051 | EIGHQRQKTPEGLQE | ubiquitination | [1] | 2086 | FQFSSQNKEYPDRED | ubiquitination | [1] | 2101 | CTTEKGKKTTVETED | ubiquitination | [1] | 2123 | QDLFVEQKERNPNID | ubiquitination | [1] | 2139 | LKVINKVKLEVQRQL | ubiquitination | [1] | 2264 | NVHPLDKKEMLKKTF | ubiquitination | [1] | 2274 | LKKTFLAKDDHKESQ | ubiquitination | [1] | 2361 | VPSHTAVKLMEKLNM | ubiquitination | [1] | 2405 | HNVLMADKAISGVLD | ubiquitination | [1] | 2422 | TQTLCSVKDAVTVGL | ubiquitination | [1] | 2432 | VTVGLLDKETATRIL | ubiquitination | [1] | 2452 | TGGIIDLKRGKKVSV | ubiquitination | [1] | 2537 | EAVRLLTKQVVDGGI | ubiquitination | [1] | 2571 | IGEDLAEKLKRVENL | ubiquitination | [1] | 2596 | KENISLPKAIKLDLI | ubiquitination | [1] | 2599 | ISLPKAIKLDLITSD | ubiquitination | [1] | 2608 | DLITSDLKREIQEVQ | ubiquitination | [1] | 2636 | RLTLAEAKKEGLLTN | ubiquitination | [1] | 2637 | LTLAEAKKEGLLTNE | ubiquitination | [1] | 2671 | VPYSELVKKCKIDIE | ubiquitination | [1] | 2672 | PYSELVKKCKIDIES | ubiquitination | [1] | 2674 | SELVKKCKIDIESGQ | ubiquitination | [1] | 2693 | VIPFSDIKDGVSDKV | ubiquitination | [1] | 2719 | VDFASTLKVLEAQAN | ubiquitination | [1] | 2737 | IIDTATGKRLTLASA | ubiquitination | [1] | 2785 | TLVEAIEKRLISPEL | ubiquitination | [1] | 2862 | ENQSAQEKVKVRVSD | ubiquitination | [1] | 2899 | PRMSSDAKEFISIIN | ubiquitination | [1] | 2913 | NPHNLKGKSLGQVSL | ubiquitination | [1] | 3051 | DEHDSHIKSQPREMT | ubiquitination | [1] | 3104 | ALTLFSSKQANEGKV | ubiquitination | [1] | 3311 | LGSFLPEKLFKGVSQ | ubiquitination | [1] | 3319 | LFKGVSQKENTGQQN | ubiquitination | [1] | 3422 | RNIEMRTKQIQPLEL | ubiquitination | [1] | 3490 | KDAKNLQKSLSSVSD | ubiquitination | [1] | 3538 | LRAWVGNKNLILNSK | ubiquitination | [1] |
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Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | |
Sequence Annotation | |
Keyword | Actin-binding; Calcium; Complete proteome; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 7592 AA |
Protein Sequence | MSSSDEETLS ERSCRSERSC RSERSYRSER SGSLSPCPPG DTLPWNLPLH EQKKRKSQDS 60 VLDPAERAVV RVADERDRVQ KKTFTKWVNK HLMKVRKHIN DLYEDLRDGH NLISLLEVLS 120 GIKLEPAGLK TLRLVSMPSW CHTNNEEQAE EDDDDVPREK GRMRFHRLQN VQIALDFLKQ 180 RQVKLVNIRN DDITDGNPKL TLGLIWTIIL HFQISDIYIS GESGDMSAKE KLLLWTQKVT 240 AGYTGIKCTN FSSCWSDGKM FNALIHRYRP DLVDMERVQI QSNRENLEQA FEVAERLGVT 300 RLLDAEDVDV PSPDEKSVIT YVSSIYDAFP KVPEGGEGIS ATEVDSRWQE YQSRVDSLIP 360 WIKQHTILMS DKTFPQNPVE LKALYNQYIH FKETEILAKE REKGRIEELY KLLEVWIEFG 420 RIKLPQGYHP NDVEEEWGKL IIEMLEREKS LRPAVERLEL LLQIANKIQN GALNCEEKLT 480 LAKNTLQADA AHLESGQPVQ CESDVIMYIQ ECEGLIRQLQ VDLQILRDEN YYQLEELAFR 540 VMRLQDELVT LRLECTNLYR KGHFTSLELV PPSTLTTTHL KAEPLTKATH SSSTSWFRKP 600 MTRAELVAIS SSEDEGNLRF VYELLSWVEE MQMKLERAEW GNDLPSVELQ LETQQHIHTS 660 VEELGSSVKE ARLYEGKMSQ NFHTSYAETL GKLETQYCKL KETSSFRMRH LQSLHKFVSR 720 ATAELIWLNE KEEEELAYDW SDNNSNISAK RNYFSELTME LEEKQDVFRS LQDTAELLSL 780 ENHPAKQTVE AYSAAVQSQL QWMKQLCLCV EQHVKENTAY FQFFSDAREL ESFLRNLQDS 840 IKRKYSCDHN TSLSRLEDLL QDSMDEKEQL IQSKSSVASL VGRSKTIVQL KPRSPDHVLK 900 NTISVKAVCD YRQIEITICK NDECVLEDNS QRTKWKVISP TGNEAMVPSV CFLIPPPNKD 960 AIEMASRVEQ SYQKVMALWH QLHVNTKSLI SWNYLRKDLD LVQTWNLEKL RSSAPGECHQ 1020 IMKNLQAHYE DFLQDSRDSV LFSVADRLRL EEEVEACKAR FQHLMKSMEN EDKEETVAKM 1080 YISELKNIRL RLEEYEQRVV KRIQSLASSR TDRDAWQDNA LRIAEQEHTQ EDLQQLRSDL 1140 DAVSMKCDSF LHQSPSSSSV PTLRSELNLL VEKMDHVYGL STVYLNKLKT VDVIVRSIQD 1200 AELLVKGYEI KLSQEEVVLA DLSALEAHWS TLRHWLSDVK DKNSVFSVLD EEIAKAKVVA 1260 EQMSRLTPER NLDLERYQEK GSQLQERWHR VIAQLEIRQS ELESIQEVLG DYRACHGTLI 1320 KWIEETTAQQ EMMKPGQAED SRVLSEQLSQ QTALFAEIER NQTKLDQCQK FSQQYSTIVK 1380 DYELQLMTYK AFVESQQKSP GKRRRMLSSS DAITQEFMDL RTRYTALVTL TTQHVKYISD 1440 ALRRLEEEEK VVEEEKQEHV EKVKELLGWV STLARNTQGK ATSSETKEST DIEKAILEQQ 1500 VLSEELTTKK EQVSEAIKTS QIFLAKHGHK LSEKEKKQIS EQLNALNKAY HDLCDGSANQ 1560 LQQLQSQLAH QTEQKECRAV AGVIDLGTVE IFPIFKAMQK GLLDQDTGLV LLESQVIMSG 1620 LIAPETGENL SLEEGIARNL INPQMYQQLR ELQDALALIS RLTESRGPLS VVEAIEKRII 1680 SETVGLKILE AHLATGGFSL SPSENCINLE EAFHQGLISA WLHSVLESYL RTSKNLIDPN 1740 TAEKIGLLDL MQRCIVHQES GFKLLPVKQL AGGMVSLKSG RKVSIFRAVQ EGLIDRQVTV 1800 RLLEAQLFAG GIVDPRTGHR LTVEEAVRHN LIDQDMACAI LIRQLQTGGI IDTVTGQRLT 1860 IDEAVSNDLV AAKIALVILE SLWSFMGLLW PESGEILPIT DALEQGIVST ELAHKILSNR 1920 QHIKALFLPA TTEILSWKKA IESGILDRDL ANNLKSICIP DVMPHMQLAD SAEQNINPGA 1980 AVLPCSKSHP KATASQSENL LFQLMTHSYI NVQNGQRLLL LDKELMETLT SRDEYQTSPP 2040 KVVEIGHQRQ KTPEGLQESA NVKISGTFSS GWTVRLPEFQ FSSQNKEYPD REDCTTEKGK 2100 KTTVETEDSS VENPEQDLFV EQKERNPNID ALKVINKVKL EVQRQLIGTQ REDQTAVSVR 2160 ENASRGHLLT IPPAEAEGVP LVVDKDVFSV ETPKKEHQPL RNTSFTCQNE QAHTLETEYI 2220 HDETGGSHIK PQSKKLQVQV KKTLGIKLEL KSETDGNVHP LDKKEMLKKT FLAKDDHKES 2280 QEAQNIAGGS MMMSEKTDEE DSGREIFLSC SHPLELLEEA TLNVLSAQLL DGGIFHEQTG 2340 QKLLLNEAIS RGIVPSHTAV KLMEKLNMFQ GFFDSQTCES LTTEEVINEG LMDEKLLHNV 2400 LMADKAISGV LDPRTQTLCS VKDAVTVGLL DKETATRILE RQVVTGGIID LKRGKKVSVT 2460 LASTLGLVDV ADQPELINLE KASKGRDAEK TVRERLISLQ METTGLIDPD SKAPLTVVQS 2520 IDRGLLEREE AVRLLTKQVV DGGIIHHISG MRLSVDNAFR HGLIGEDLAE KLKRVENLNI 2580 HQIFNPETKE NISLPKAIKL DLITSDLKRE IQEVQAFTGN FVDLISGQRL TLAEAKKEGL 2640 LTNEAVLSPG MMHGIVDPEN CRIVPYSELV KKCKIDIESG QRYLEVIPFS DIKDGVSDKV 2700 LTLSQAIQLG KVDFASTLKV LEAQANTGGI IDTATGKRLT LASALEEKLV DENMVRIIAS 2760 HQVLNGGIVD IFSDQRVTLV EAIEKRLISP ELANMIQIDS SEFSDHRAQI EKQEGIEVCA 2820 LQNEFLGKDM LIACNQTAEM SCNKVEESER LFQVENQSAQ EKVKVRVSDG EQAKKSREIS 2880 LKEFGCKDQR KPRMSSDAKE FISIINPHNL KGKSLGQVSL THPYSECDFK LKEVARNNMG 2940 NDTNEEQEKA VTKIEIISHM KQSTSCLDSE EIRENQGEVI LEVQETYCET SGKLPSEQVL 3000 QQPMNARVKS KREKREVIVE ESIRTCKPAF LSEEKLYQET AIRDEHDSHI KSQPREMTSS 3060 EKGKEADTEM GFSITFKIEE SSSQVVPQGI SVKHLDALTL FSSKQANEGK VNNLSLCLTL 3120 KPEENLSREI ACGAQSEPFP CMTPRPEGLH YQESDGKAQV TGPSQISKTD KSFQGTTRQE 3180 TNYQDSWVTS KTKETKHQIS SSNECKEKSY QEVSFDPARG LKLEEITVSR PDSKEVRYLE 3240 FSDRKDLHHQ GSKSDDKLCG TLKSEIATQE LTGEKFLEMA NPNVAGLEAG SIEDIVTQRG 3300 SRVLGSFLPE KLFKGVSQKE NTGQQNAIIS PTVLETSEEK TVSLTVCSAV KTEKTPQEKL 3360 RESPGSEQTP FMTAPEGKGN GGVNPEPFRA TQNVFTRQLC LEHDEKLVSY LSLLRNIEMR 3420 TKQIQPLELN LAELQDLLCQ AKVLERELKD LTTLVSQELE CVNQIIISQP QEVPAQLLKA 3480 LEKDAKNLQK SLSSVSDTWN SRLLHFQNAV EIEKTKVLNQ HTQLEGRLQD LRAWVGNKNL 3540 ILNSKGSNSE IDVDSLNLCL QQYEDLKQPM AERKAQLDAL AFDIQFFISE HAQDLSPQQN 3600 RQMLRLLNEL QRSFQDILEQ TAAQVDALQG HLQQMEQEAL VKTLQKQQNT CHQQLEDLCS 3660 WVGQAERALA GHQGRTTQQD LSALQKNQSD LKDLQDDIQN RATSFATVVK DIEGFMEENQ 3720 TKLSPRELTA LREKLHQAKE QYEALQEETR VAQKELEEAV TSALQQETEK SKAAKELAEN 3780 KKKIDALLDW VTSVGSSGGQ LLTNLPGMEQ LSGASLEKGA LDTTDGYMGV NQAPEKLDKQ 3840 CEMMKARHQE LLSQQQNFIL ATQSAQAFLD QHGHNLTPEE QQMLQQKLGE LKEQYSTSLA 3900 QSEAELKQVQ TLQDELQKFL QDHKEFESWL ERSEKELENM HKGGSSPETL PSLLKRQGSF 3960 SEDVISHKGD LRFVTISGQK VLDMENSFKE GKEPSEIGNL VKDKLKDATE RYTALHSKCT 4020 RLGSHLNMLL GQYHQFQNSA DSLQAWMQAC EANVEKLLSD TVASDPGVLQ EQLATTKQLQ 4080 EELAEHQVPV EKLQKVARDI MEIEGEPAPD HRHVQETTDS ILSHFQSLSY SLAERSSLLQ 4140 KAIAQSQSVQ ESLESLLQSI GEVEQNLEGK QVSSLSSGVI QEALATNMKL KQDIARQKSS 4200 LEATREMVTR FMETADSTTA AVLQGKLAEV SQRFEQLCLQ QQEKESSLKK LLPQAEMFEH 4260 LSGKLQQFME NKSRMLASGN QPDQDITHFF QQIQELNLEM EDQQENLDTL EHLVTELSSC 4320 GFALDLCQHQ DRVQNLRKDF TELQKTVKER EKDASSCQEQ LDEFRKLVRT FQKWLKETEG 4380 SIPPTETSMS AKELEKQIEH LKSLLDDWAS KGTLVEEINC KGTSLENLIM EITAPDSQGK 4440 TGSILPSVGS SVGSVNGYHT CKDLTEIQCD MSDVNLKYEK LGGVLHERQE SLQAILNRME 4500 EVHKEANSVL QWLESKEEVL KSMDAMSSPT KTETVKAQAE SNKAFLAELE QNSPKIQKVK 4560 EALAGLLVTY PNSQEAENWK KIQEELNSRW ERATEVTVAR QRQLEESASH LACFQAAESQ 4620 LRPWLMEKEL MMGVLGPLSI DPNMLNAQKQ QVQFMLKEFE ARRQQHEQLN EAAQGILTGP 4680 GDVSLSTSQV QKELQSINQK WVELTDKLNS RSSQIDQAIV KSTQYQELLQ DLSEKVRAVG 4740 QRLSVQSAIS TQPEAVKQQL EETSEIRSDL EQLDHEVKEA QTLCDELSVL IGEQYLKDEL 4800 KKRLETVALP LQGLEDLAAD RINRLQAALA STQQFQQMFD ELRTWLDDKQ SQQAKNCPIS 4860 AKLERLQSQL QENEEFQKSL NQHSGSYEVI VAEGESLLLS VPPGEEKRTL QNQLVELKNH 4920 WEELSKKTAD RQSRLKDCMQ KAQKYQWHVE DLVPWIEDCK AKMSELRVTL DPVQLESSLL 4980 RSKAMLNEVE KRRSLLEILN SAADILINSS EADEDGIRDE KAGINQNMDA VTEELQAKTG 5040 SLEEMTQRLR EFQESFKNIE KKVEGAKHQL EIFDALGSQA CSNKNLEKLR AQQEVLQALE 5100 PQVDYLRNFT QGLVEDAPDG SDASQLLHQA EVAQQEFLEV KQRVNSGCVM MENKLEGIGQ 5160 FHCRVREMFS QLADLDDELD GMGAIGRDTD SLQSQIEDVR LFLNKIHVLK LDIEASEAEC 5220 RHMLEEEGTL DLLGLKRELE ALNKQCGKLT ERGKARQEQL ELTLGRVEDF YRKLKGLNDA 5280 TTAAEEAEAL QWVVGTEVEI INQQLADFKM FQKEQVDPLQ MKLQQVNGLG QGLIQSAGKD 5340 CDVQGLEHDM EEINARWNTL NKKVAQRIAQ LQEALLHCGK FQDALEPLLS WLADTEELIA 5400 NQKPPSAEYK VVKAQIQEQK LLQRLLDDRK ATVDMLQAEG GRIAQSAELA DREKITGQLE 5460 SLESRWTELL SKAAARQKQL EDILVLAKQF HETAEPISDF LSVTEKKLAN SEPVGTQTAK 5520 IQQQIIRHKA LEEDIENHAT DVHQAVKIGQ SLSSLTSPAE QGVLSEKIDS LQARYSEIQD 5580 RCCRKAALLD QALSNARLFG EDEVEVLNWL AEVEDKLSSV FVKDFKQDVL HRQHADHLAL 5640 NEEIVNRKKN VDQAIKNGQA LLKQTTGEEV LLIQEKLDGI KTRYADITVT SSKALRTLEQ 5700 ARQLATKFQS TYEELTGWLR EVEEELATSG GQSPTGEQIP QFQQRQKELK KEVMEHRLVL 5760 DTVNEVSRAL LELVPWRARE GLDKLVSDAN EQYKLVSDTI GQRVDEIDAA IQRSQQYEQA 5820 ADAELAWVAE TKRKLMALGP IRLEQDQTTA QLQVQKAFSI DIIRHKDSMD ELFSHRSEIF 5880 GTCGEEQKTV LQEKTESLIQ QYEAISLLNS ERYARLERAQ VLVNQFWETY EELSPWIEET 5940 RALIAQLPSP AIDHEQLRQQ QEEMRQLRES IAEHKPHIDK LLKIGPQLKE LNPEEGEMVE 6000 EKYQKAENMY AQIKEEVRQR ALALDEAVSQ STQFHDKIEP MLETLENLSS RLRMPPLIPA 6060 EVDKIRECIS DNKSATVELE KLQPSFEALK RRGEELIGRS QGADKDLAAK EIQDKLDQMV 6120 FFWEDIKARA EEREIKFLDV LELAEKFWYD MAALLTTIKD TQDIVHDLES PGIDPSIIKQ 6180 QVEAAETIKE ETDGLHEELE FIRILGADLI FACGETEKPE VRKSIDEMNN AWENLNKTWK 6240 ERLEKLEDAM QAAVQYQDTL QAMFDWLDNT VIKLCTMPPV GTDLNTVKDQ LNEMKEFKVE 6300 VYQQQIEMEK LNHQGELMLK KATDETDRDI IREPLTELKH LWENLGEKIA HRQHKLEGAL 6360 LALGQFQHAL EELMSWLTHT EELLDAQRPI SGDPKVIEVE LAKHHVLKND VLAHQATVET 6420 VNKAGNELLE SSAGDDASSL RSRLEAMNQC WESVLQKTEE REQQLQSTLQ QAQGFHSEIE 6480 DFLLELTRME SQLSASKPTG GLPETAREQL DTHMELYSQL KAKEETYNQL LDKGRLMLLS 6540 RDDSGSGSKT EQSVALLEQK WHVVSSKMEE RKSKLEEALN LATEFQNSLQ EFINWLTLAE 6600 QSLNIASPPS LILNTVLSQI EEHKVFANEV NAHRDQIIEL DQTGNQLKFL SQKQDVVLIK 6660 NLLVSVQSRW EKVVQRSIER GRSLDDARKR AKQFHEAWKK LIDWLEDAES HLDSELEISN 6720 DPDKIKLQLS KHKEFQKTLG GKQPVYDTTI RTGRALKEKT LLPEDSQKLD NFLGEVRDKW 6780 DTVCGKSVER QHKLEEALLF SGQFMDALQA LVDWLYKVEP QLAEDQPVHG DLDLVMNLMD 6840 AHKVFQKELG KRTGTVQVLK RSGRELIENS RDDTTWVKGQ LQELSTRWDT VCKLSVSKQS 6900 RLEQALKQAE VFRDTVHMLL EWLSEAEQTL RFRGALPDDT EALQSLIDTH KEFMKKVEEK 6960 RVDVNSAVAM GEVILAVCHP DCITTIKHWI TIIRARFEEV LTWAKQHQQR LETALSELVA 7020 NAELLEELLA WIQWAETTLI QRDQEPIPQN IDRVKALIAE HQTFMEEMTR KQPDVDRVTK 7080 TYKRKNIEPT HAPFIEKSRS GGRKSLSQPT PPPMPILSQS EAKNPRINQL SARWQQVWLL 7140 ALERQRKLND ALDRLEELKE FANFDFDVWR KKYMRWMNHK KSRVMDFFRR IDKDQDGKIT 7200 RQEFIDGILA SKFPTTKLEM TAVADIFDRD GDGYIDYYEF VAALHPNKDA YRPTTDADKI 7260 EDEVTRQVAQ CKCAKRFQVE QIGENKYRFF LGNQFGDSQQ LRLVRILRST VMVRVGGGWM 7320 ALDEFLVKND PCRVHHPGSK IKRSDSSSSI SSQSPIARGR TNIELREKFI LPEGASQGMT 7380 PFRSRGRRSK PSSRAASPTR SSSSASQSNH SCTSMPSSPA TPASGTKTSL QFSRCYDKPW 7440 LVNSKAGTPI RDSHSPDLQL PTPEVIPSSG SKLKRPTPTF HSSRTSLAGD TSNSSSPAST 7500 GAKTNRADPK KSASRPGSRA GSRAGSRASS RRGSDASDFD LLETQSACSD TSESSAAGGQ 7560 GNSRRGLNKP SKIPTMSKKT TTASPRTPGP KR 7592 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |