CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022401
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Pleckstrin-2 
Protein Synonyms/Alias
  
Gene Name
 PLEK2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
135SLHRIVDKMHDSNTGubiquitination[1]
156MEQGSTYKKTFLGSSubiquitination[1]
314NGVPTGVKGNVQGNLubiquitination[1]
339YYIQASSKAERAEWIubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 May help orchestrate cytoskeletal arrangement. Contribute to lamellipodia formation. 
Sequence Annotation
 DOMAIN 4 104 PH 1.
 DOMAIN 139 225 DEP.
 DOMAIN 247 353 PH 2.  
Keyword
 3D-structure; Cell membrane; Cell projection; Complete proteome; Cytoplasm; Cytoskeleton; Membrane; Polymorphism; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 353 AA 
Protein Sequence
MEDGVLKEGF LVKRGHIVHN WKARWFILRQ NTLVYYKLEG GRRVTPPKGR ILLDGCTITC 60
PCLEYENRPL LIKLKTQTST EYFLEACSRE ERDAWAFEIT GAIHAGQPGK VQQLHSLRNS 120
FKLPPHISLH RIVDKMHDSN TGIRSSPNME QGSTYKKTFL GSSLVDWLIS NSFTASRLEA 180
VTLASMLMEE NFLRPVGVRS MGAIRSGDLA EQFLDDSTAL YTFAESYKKK ISPKEEISLS 240
TVELSGTVVK QGYLAKQGHK RKNWKVRRFV LRKDPAFLHY YDPSKEENRP VGGFSLRGSL 300
VSALEDNGVP TGVKGNVQGN LFKVITKDDT HYYIQASSKA ERAEWIEAIK KLT 353 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0031258; C:lamellipodium membrane; IEA:UniProtKB-SubCell.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0030036; P:actin cytoskeleton organization; TAS:ProtInc.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro. 
Interpro
 IPR000591; DEP_dom.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR011991; WHTH_DNA-bd_dom. 
Pfam
 PF00610; DEP
 PF00169; PH 
SMART
 SM00049; DEP
 SM00233; PH 
PROSITE
 PS50186; DEP
 PS50003; PH_DOMAIN 
PRINTS