UniProt Accession

 RNC_MYCPN; P75233 

Genbank Protein ID

 U00089 

Genbank Nucleotide ID

 AAB95945.1 

Protein Name

 Ribonuclease 3 

Protein Synonyms/Alias

 Ribonuclease III; RNase III 

Gene Name

 rnc 

Gene Synonyms/Alias

 MPN_545; MP297 

Created Date

 July 27, 2013 

Organism

 Mycoplasma pneumoniae (strain ATCC 29342 / M129) 

NCBI Taxa ID

 272634 

Lysine Modification

Position	Peptide	Type	References
17	KPKVIDEKFVAFFKS	acetylation	[1]

Reference

 [1] Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium.
 van Noort V, Seebacher J, Bader S, Mohammed S, Vonkova I, Betts MJ, Kühner S, Kumar R, Maier T, O'Flaherty M, Rybin V, Schmeisky A, Yus E, Stülke J, Serrano L, Russell RB, Heck AJ, Bork P, Gavin AC.
 Mol Syst Biol. 2012 Feb 28;8:571. [PMID: 22373819] 

Functional Description

 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity). 

Sequence Annotation

 DOMAIN 18 141 RNase III.
 ACT_SITE 63 63 Potential.
 ACT_SITE 130 130 By similarity.
 METAL 59 59 Magnesium (By similarity).
 METAL 127 127 Magnesium (By similarity).
 METAL 130 130 Magnesium (By similarity).  

Keyword

 Complete proteome; Cytoplasm; Endonuclease; Hydrolase; Magnesium; Metal-binding; mRNA processing; Nuclease; Reference proteome; rRNA processing; tRNA processing. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 282 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004525; F:ribonuclease III activity; IEA:HAMAP.
 GO:0003723; F:RNA binding; IEA:InterPro.
 GO:0006397; P:mRNA processing; IEA:HAMAP.
 GO:0090305; P:nucleic acid phosphodiester bond hydrolysis; IEA:GOC.
 GO:0016075; P:rRNA catabolic process; IEA:InterPro.
 GO:0006364; P:rRNA processing; IEA:HAMAP.
 GO:0008033; P:tRNA processing; IEA:UniProtKB-KW. 

Interpro

 IPR011907; RNase_III.
 IPR000999; RNase_III_dom. 

Pfam

 PF00636; Ribonuclease_3 

SMART

 SM00535; RIBOc 

PROSITE

 PS00517; RNASE_3_1
 PS50142; RNASE_3_2 

PRINTS