CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034272
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Histone-lysine N-methyltransferase NSD3 
Protein Synonyms/Alias
  
Gene Name
 Whsc1l1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
481PPVKIAWKTAAARKSacetylation[1]
542STKGIGNKTEISVRGacetylation[1]
800PTAIFESKGFRCPQHacetylation[1, 2, 3]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Methyltransferase; Nucleus; Reference proteome; Transferase; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1397 AA 
Protein Sequence
MDFSFSFMQG IMGNTIQQPP QLIDSANIRQ EDAFDNHSDI VEDGGPTPFE ATLQQGFQYP 60
PTTEDLPPLT NGYPPSISLY ETQTKYPPYN QYPNGSANGF GAVRNFSPTD YYHSEIPNTR 120
PHEILEKPSP PQPPPLPPPP PPPPPPPSVP QTVIPKKTGS PEIKLKITKT IQNGRELFES 180
SLCGDLLNEV QASEHTKSKH ESRKEKRKKS NRHESSRSEE RRSHKIPKLE PEGQNRPNER 240
VDTAPEKPRE EPVLKEAIPV QPILSSVPTT ETSTGVKFQV GDLVWSKVGT YPWWPCMVSS 300
DPQLEVHSKI NTRGAREYHV QFFSNQPERA WVHEKRVREY KGHEQYEELL AEAAKQASNH 360
SEKQKIRKPR PQRERAQWDI GIAHAEKALK MTREERVEQY TFIYIDKQPE EASSQAKKNV 420
TSKTEVKKPR RPRSVLNSQP EQTNAGEVAS SQSSTDLRRQ SQRRHTSLEE EEPPPVKIAW 480
KTAAARKSLP ASITMHKGSL DLQKCNMSPV VKIEQVFALQ NATGDGKFID QFVYSTKGIG 540
NKTEISVRGQ DRLIISSPSQ RSEKPAQSAS SPEATSGSAG PVEKKQQRRS IRTRSESEKS 600
AEVVPKKKIK KEQVETAPQA SLKTGLQKGA SEISDSCKPL KKRSRASTDV ETASCTYRDT 660
SDSDSRGLSD GQVGFGKQVD SPSATADADA SDAQSVDSSL SRRGVGTSKK DTVCQVCEKA 720
GDCLVACEGE CCRHFHVECL GLTAVPEGHF TCEECETGQH PCFSCKVSGK DVKRCSVSVC 780
GKFYHEACVR KFPTAIFESK GFRCPQHCCS SCSMEKDIHK ASKGRMMRCL RCPVAYHVGD 840
ACVAAGSVSV SSHILICSNH SKRSSQSAAI NVGFCFVCAR GGRLLCCESC PASFHPECLS 900
IDMPEGCWNC NDCKAGKKLH YKQIVWVKLG NYRWWPAEIC SPRSVPLNIQ GLKHDLGDFP 960
VFFFGSHDYY WVHQGRVFPY VEGDKHFAEG QTSINKTFKK ALEEAAKRFQ ELKAQRESKE 1020
ALEMERTSRK PPPYKHIKAN KVIGKVQVQV ADLSEIPRCN CKPGDENPCG LESQCLNRMS 1080
QYECHPQVCP AGDRCQNQCF TKRLYPDAEV IKTERRGWGL RTKRSIKKGE FVNEYVGELI 1140
DEEECRLRIK RAHENSVTNF YMLTVTKDRI IDAGPKGNYS RFMNHSCNPN CETQKWTVNG 1200
DVRVGLFALC DIPAGMELTF NYNLDCLGNG RTVCHCGADN CSGFLGVRPK SACTSAVDEK 1260
TKNAKLKKRR KVKAEAKPIH EDYCFQCGDG GELVMCDKKD CPKAYHLLCL NLTQPPHGKW 1320
ECPWHRCDEC GSVAVSFCEF CPHSFCKAHG KGALVPSALE GRLCCSSHDP ASPVSPEYWS 1380
KIRCKWESQD SGEEVKE 1397 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-KW.
 GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0034968; P:histone lysine methylation; IEA:GOC. 
Interpro
 IPR006560; AWS.
 IPR003616; Post-SET_dom.
 IPR000313; PWWP.
 IPR001214; SET_dom.
 IPR019786; Zinc_finger_PHD-type_CS.
 IPR011011; Znf_FYVE_PHD.
 IPR001965; Znf_PHD.
 IPR019787; Znf_PHD-finger.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF00855; PWWP
 PF00856; SET 
SMART
 SM00570; AWS
 SM00249; PHD
 SM00508; PostSET
 SM00293; PWWP
 SM00317; SET 
PROSITE
 PS51215; AWS
 PS50868; POST_SET
 PS50812; PWWP
 PS50280; SET
 PS01359; ZF_PHD_1
 PS50016; ZF_PHD_2 
PRINTS