UniProt Accession

 PLS2_MOUSE; Q9DCW2; O70233; Q921P6 

Genbank Protein ID

 AF015790; AK002410; CH466560; BC002012; BC011299 

Genbank Nucleotide ID

 AAC40053.1; BAB22079.1; EDL20918.1; AAH02012.1; AAH11299.1 

Protein Name

 Phospholipid scramblase 2 

Protein Synonyms/Alias

 PL scramblase 2; Ca(2+)-dependent phospholipid scramblase 2 

Gene Name

 Plscr2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
221	KLTLQNDKRENVLKV	ubiquitination	[1]
259	TRIGKITKQWSGCVK	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. 

Sequence Annotation

 MOTIF 11 20 SH3-binding 1 (Potential).
 MOTIF 82 89 SH3-binding 2 (Potential).
 MOD_RES 159 159 Phosphothreonine; by PKC (By similarity).
 LIPID 232 232 S-palmitoyl cysteine (Probable).
 LIPID 235 235 S-palmitoyl cysteine (Probable).
 LIPID 237 237 S-palmitoyl cysteine (Probable).
 LIPID 238 238 S-palmitoyl cysteine (Probable).  

Keyword

 Calcium; Complete proteome; Lipoprotein; Membrane; Metal-binding; Palmitate; Phosphoprotein; Reference proteome; Repeat; SH3-binding; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 307 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0071222; P:cellular response to lipopolysaccharide; IEP:UniProtKB. 

Interpro

 IPR005552; Scramblase. 

Pfam

 PF03803; Scramblase 

SMART

  

PROSITE

  

PRINTS