| Tag | Content |
|---|
| CPLM ID | CPLM-008341 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Polyphosphatidylinositol phosphatase INP52 |
Protein Synonyms/Alias | Synaptojanin-like protein 2; SAC1-like phosphoinositide phosphatase; Phosphatidylinositol 4,5-bisphosphate 5-phosphatase |
Gene Name | INP52 |
Gene Synonyms/Alias | SJL2; YNL106C; N2160 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 91 | VAQPIPNKTVNKIYA | ubiquitination | [1] | | 791 | RRELRAQKDGYIDRL | ubiquitination | [1] | | 842 | DNYDTSEKARTPSWT | ubiquitination | [1] | | 1147 | KVSPSNSKSEEELPC | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Dephosphorylates a number of phosphatidylinositols (PIs) like phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), but also phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Controls the cellular levels and subcellular distribution of phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5- bisphosphate. Specifically functions within the early endocytic pathway and actin organization. |
Sequence Annotation | DOMAIN 167 507 SAC.
MOD_RES 152 152 Phosphoserine.
MOD_RES 522 522 Phosphoserine.
MOD_RES 1005 1005 Phosphoserine.
MOD_RES 1016 1016 Phosphoserine.
MOD_RES 1032 1032 Phosphothreonine. |
Keyword | Complete proteome; Cytoplasm; Cytoskeleton; Endocytosis; Hydrolase; Lipid metabolism; Phosphoprotein; Protein transport; Reference proteome; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1183 AA |
Protein Sequence | MKILLSKQQT RKIAIVSETH GLVFRPINSK NSRRSTCAVE LVPKAELNGN GFRRLSNHEI 60
YGFIGLIEIE GLMFIATITG KSKVAQPIPN KTVNKIYAVD FFCLNNSKWD FMDIDSSGYP 120
IVTNDGDFAI SSPPSISTHS SRSSLRSSSS RSLNAQEQAP KHPCHELRKL LSNGSFYYST 180
DFDLTCTLQK RGFTEHSLSF DDFDREFMWN SFLMDEIITY RDRLDVTAKE LLDQRGFLTT 240
VIRGFAETIF SYINRLKVGL TIISRQSWKR AGTRFNARGI DDDGHVANFV ETEMIMYSSQ 300
YCYAFTQIRG SLPIFWEQDT SLISPKIQIT RSVEATQPTF DEHFIRLFKK YGPVHIINLL 360
STKSSEIQLS RRYKEQLKNS EKMKIGRDVF LTSFDFHRET SQDGFAAASR IIPKIRNTIL 420
DAGYFSYDVK EGRLISEQDG VFRTNCLDCL DRTNLIQQTI SLAVFKLFLE DFRLVKPSSF 480
IDDNEFVQKV NALWADNGDQ ISQIYTGTNA LKSSYSRKGK MSFSGALSDA TKSVSRMYIN 540
NFVDKGKQQN IDTLLGKLPH QQVVELYDPI CEYVNERLLE SEEKFTTHSN INLFVGTFNV 600
NGNSRRADLS KWLFPIGDKF KPDVVVLGLQ EVIELTAGSI LNADYTKSSF WETMVTDCLN 660
QYEEKYLLLR VEQMSSLLIL FFARSDRAYN IKEVGGSTKK TGFGGITGNK GAVAIRFDYG 720
ATSFCFVNTH LSAGASNIDE RRNDYNNIYR NITFPRSKTI PHHDSLFWLG DLNYRITLTN 780
DEVRRELRAQ KDGYIDRLLQ YDQLTQEINE GVVFQGFKEP TLQFRPTYKY DYGTDNYDTS 840
EKARTPSWTD RIIYKGENLH PLAYSDAPLK ISDHKPVYAA YRANVKFVDE KEKLNLVEKL 900
YAEYKNTHPE ALTTGPDELS HARMEKQKES IPLDATVQSA GIKLIDLDDT SSCVSPLLSG 960
PSPQPSVVGP GGLSNVSPDK SKLNVLPPPP PTSRHNKEPS SKLLSPTKEI SIVSVSPRKG 1020
ESNLPALERH STPKPLPPVP ALSLSKPVSL QKSSSELQHA KETIDNGKIV PRPCPPIRRK 1080
SSTAPDEIST STKNSGVSTT EDPEPAKAST KPEKPPVVKK PHYLSVAANK LNTSQEHSIK 1140
VSPSNSKSEE ELPCKKKSKP KVPAKNPELE KLSVHPLKPC DPN 1183 |
Gene Ontology | GO:0030479; C:actin cortical patch; IDA:SGD. GO:0043332; C:mating projection tip; IDA:SGD. GO:0043813; F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity; IDA:SGD. GO:0004438; F:phosphatidylinositol-3-phosphatase activity; IDA:SGD. GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IDA:SGD. GO:0043812; F:phosphatidylinositol-4-phosphate phosphatase activity; IDA:SGD. GO:0006897; P:endocytosis; IEA:UniProtKB-KW. GO:0046856; P:phosphatidylinositol dephosphorylation; IDA:SGD. GO:0015031; P:protein transport; IEA:UniProtKB-KW. |
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