UniProt Accession

 IN80C_HUMAN; Q6PI98; B4DUI4; E9PCS7; Q86WR1; Q8N994 

Genbank Protein ID

 AK095502; AK300660; AC007998; BC039404 

Genbank Nucleotide ID

 BAC04560.1; BAG62346.1; AAH39404.1 

Protein Name

 INO80 complex subunit C 

Protein Synonyms/Alias

 IES6 homolog; hIes6 

Gene Name

 INO80C 

Gene Synonyms/Alias

 C18orf37 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
21	PGIVRNSKKRPASPS	ubiquitination	[1, 2]
22	GIVRNSKKRPASPSH	ubiquitination	[1, 2]
41	GGGYGASKKKKASAS	ubiquitination	[1, 2]
109	NRTWKNLKQILASER	ubiquitination	[3]
137	IDAPPSFKPAKKYSD	ubiquitination	[4]
141	PSFKPAKKYSDVSGL	ubiquitination	[3]

Reference

 [1] Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry.
 Denis NJ, Vasilescu J, Lambert JP, Smith JC, Figeys D.
 Proteomics. 2007 Mar;7(6):868-74. [PMID: 17370265]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 

Functional Description

 Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. 

Sequence Annotation

 CROSSLNK 21 21 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 22 22 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 41 41 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Alternative splicing; Complete proteome; DNA damage; DNA recombination; DNA repair; Isopeptide bond; Nucleus; Reference proteome; Transcription; Transcription regulation; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 192 AA 

Protein Sequence

Gene Ontology

 GO:0031011; C:Ino80 complex; IDA:UniProtKB.
 GO:0071339; C:MLL1 complex; IDA:UniProtKB.
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
 GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR013272; YL1_C. 

Pfam

 PF08265; YL1_C 

SMART

 SM00993; YL1_C 

PROSITE

  

PRINTS