CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001704
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Peroxisomal membrane protein 11B 
Protein Synonyms/Alias
 Peroxin-11B; Peroxisomal biogenesis factor 11B; Protein PEX11 homolog beta; PEX11-beta 
Gene Name
 PEX11B 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
43GASPELQKQIRQLESacetylation[1, 2]
43GASPELQKQIRQLESubiquitination[3, 4]
72ADALESAKRAVHLSDubiquitination[3]
107DNVLWAGKSGLAPRVubiquitination[3]
158SACSRRLKGSGGGVPubiquitination[3]
224DLFIPLDKLGLWRCGubiquitination[3]
Reference
 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Involved in peroxisomal proliferation. May regulate peroxisomes division by recruiting the dynamin-related GTPase DNM1L to the peroxisomal membrane. 
Sequence Annotation
 REGION 211 259 Interaction with PEX19 and peroxisome
 MOD_RES 43 43 N6-acetyllysine.  
Keyword
 Acetylation; Alternative splicing; Complete proteome; Membrane; Peroxisome; Peroxisome biogenesis; Peroxisome biogenesis disorder; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 259 AA 
Protein Sequence
MDAWVRFSAQ SQARERLCRA AQYACSLLGH ALQRHGASPE LQKQIRQLES HLSLGRKLLR 60
LGNSADALES AKRAVHLSDV VLRFCITVSH LNRALYFACD NVLWAGKSGL APRVDQEKWA 120
QRSFRYYLFS LIMNLSRDAY EIRLLMEQES SACSRRLKGS GGGVPGGSET GGLGGPGTPG 180
GGLPQLALKL RLQVLLLARV LRGHPPLLLD VVRNACDLFI PLDKLGLWRC GPGIVGLCGL 240
VSSILSILTL IYPWLRLKP 259 
Gene Ontology
 GO:0005779; C:integral to peroxisomal membrane; IDA:UniProtKB.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0043234; C:protein complex; IDA:UniProtKB.
 GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
 GO:0016559; P:peroxisome fission; IDA:UniProtKB.
 GO:0051260; P:protein homooligomerization; IDA:UniProtKB.
 GO:0044375; P:regulation of peroxisome size; IDA:UniProtKB.
 GO:0007165; P:signal transduction; ISS:UniProtKB. 
Interpro
 IPR008733; PEX11. 
Pfam
 PF05648; PEX11 
SMART
  
PROSITE
  
PRINTS