CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037004
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Dystonin 
Protein Synonyms/Alias
  
Gene Name
 DST 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
1484SSEEISTKKEQLSEAacetylation[1]
3497EVLIIQDKLEAIKARacetylation[2]
Reference
 [1] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 
Functional Description
  
Sequence Annotation
  
Keyword
 Actin-binding; Calcium; Complete proteome; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 5375 AA 
Protein Sequence
MAGYLSPAAY LYVEEQEYLQ AYEDVLERYK DERDKVQKKT FTKWINQHLM KVRKHVNDLY 60
EDLRDGHNLI SLLEVLSGDT LPREKGRMRF HRLQNVQIAL DYLKRRQVKL VNIRNDDITD 120
GNPKLTLGLI WTIILHFQIS DIHVTGESED MSAKERLLLW TQQATEGYAG IRCENFTTCW 180
RDGKLFNAII HKYRPDLIDM NTVAVQSNLA NLEHAFYVAE KIGVIRLLDP EDVDVSSPDE 240
KSVITYVSSL YDAFPKVPEG GEGIGANDVE VKWIEYQNMV NYLIQWIRHH VTTMSERTFP 300
NNPVELKALY NQYLQFKETE IPPKETEKSK IKRLYKLLEI WIEFGRIKLL QGYHPNDIEK 360
EWGKLIIAML EREKALRPEV ERLEMLQQIA NRVQRDSVIC EDKLILAGNA LQSDSKRLES 420
GVQFQNEAEI AGYILECENL LRQHVIDVQI LIDGKYYQAD QLVQRVAKLR DEIMALRNEC 480
SSVYSKGRIL TTEQTKLMIS GITQSLNSGF AQTLHPSLTS GLTQSLTPSL TSSSMTSGLS 540
SGMTSRLTPS VTPAYTPGFP SGLVPNFSSG VEPNSLQTLK LMQIRKPLLK SSLLDQNLTE 600
EEINMKFVQD LLNWVDEMQV QLDRTEWGSD LPSVESHLEN HKNVHRAIEE FESSLKEAKI 660
SEIQMTAPLK LTYAEKLHRL ESQYAKLLNT SRNQERHLDT LHNFVSRATN ELIWLNEKEE 720
EEVAYDWSER NTNIARKKDY HAELMRELDQ KEENIKSVQE IAEQLLLENH PARLTIEAYR 780
AAMQTQWSWI LQLCQCVEQH IKENTAYFEF FNDAKEATDY LRNLKDAIQR KYSCDRSSSI 840
HKLEDLVQES MEEKEELLQY KSTIANLMGK AKTIIQLKPR NSDCPLKTSI PIKAICDYRQ 900
IEITIYKDDE CVLANNSHRA KWKVISPTGN EAMVPSVCFT VPPPNKEAVD LANRIEQQYQ 960
NVLTLWHESH INMKSVVSWH YLINEIDRIR ASNVASIKTM LPGEHQQVLS NLQSRFEDFL 1020
EDSQESQVFS GSDITQLEKE VNVCKQYYQE LLKSAEREEQ EESVYNLYIS EVRNIRLRLE 1080
NCEDRLIRQI RTPLERDDLH ESVFRITEQE KLKKELERLK DDLGTITNKC EEFFSQAAAS 1140
SSVPTLRSEL NVVLQNMNQV YSMSSTYIDK LKTVNLVLKN TQAAEALVKL YETKLCEEEA 1200
VIADKNNIEN LISTLKQWRS EVDEKRQVFH ALEDELQKAK AISDEMFKTY KERDLDFDWH 1260
KEKADQLVER WQNVHVQIDN RLRDLEGIGK SLKYYRDTYH PLDDWIQQVE TTQRKIQENQ 1320
PENSKTLATQ LNQQKMLVSE IEMKQSKMDE CQKYAEQYSA TVKDYELQTM TYRAMVDSQQ 1380
KSPVKRRRMQ SSADLIIQEF MDLRTRYTAL VTLMTQYIKF AGDSLKRLEE EEKSLEEEKK 1440
EHVEKAKELQ KWVSNISKTL KDAEKAGKPP FSKQKISSEE ISTKKEQLSE ALQTIQLFLA 1500
KHGDKMTDEE RNELEKQVKT LQESYNLLFS ESLKQLQESQ TSGDVKVEEK IVAERQQEYK 1560
EKLQGICDLL TQTENRLIGH QEAFMIGDGT VELKKYQSKQ EELQKDMQGS AQALAEVVKN 1620
TENFLKENGE KLSQEDKALI EQKLNEAKIK CEQLNLKAEQ SKKELDKVVT TAIKEETEKV 1680
AAVKQLEESK TKIENLLDWL SNVDKDSERA GTKHKQVIEQ NGTHFQEGDG KSAIGEEDEV 1740
NGNLLETDVD GQVGTTQENL NQQYQKVKAQ HEKIISQHQA VIIATQSAQV LLEKQGQYLS 1800
PEEKEKLQKN MKELKVHYET ALAESEKKMK LTHSLQEELE KFDADYTEFE HWLQQSEQEL 1860
ENLEAGADDI NGLMTKLKRQ KSFSEDVISH KGDLRYITIS GNRVLEAAKS CSKRDGGKVD 1920
TSATHREVQR KLDHATDRFR SLYSKCNVLG NNLKDLVDKY QHYEDASCGL LAGLQACEAT 1980
ASKHLSEPIA VDPKNLQRQL EETKALQGQI SSQQVAVEKL KKTAEVLLDA RGSLLPAKND 2040
IQKTLDDIVG RYEDLSKSVN ERNEKLQITL TRSLSVQDGL DEMLDWMGNV ESSLKEQGQV 2100
PLNSTALQDI ISKNIMLEQD IAGRQSSINA MNEKVKKFME TTDPSTASSL QAKMKDLSAR 2160
FSEASHKHKE TLAKMEELKT KVELFENLSE KLQTFLETKT QALTEVDVPG KDVTELSQYM 2220
QESTSEFLEH KKHLEVLHSL LKEISSHGLP SDKALVLEKT NNLSKKFKEM EDTIKEKKEA 2280
VTSCQEQLDA FQVLVKSLKS WIKETTKKVP IVQPSFGAED LGKSLEDTKK LQEKWSLKTP 2340
EIQKVNNSGI SLCNLISAVT TPAKAIAAVK SGGAVLNGEG TATNTEEFWA NKGLTSIKKD 2400
MTDISHGYED LGLLLKDKIA ELNTKLSKLQ KAQEESSAMM QWLQKMNKTA TKWQQTPAPT 2460
DTEAVKTQVE QNKSFEAELK QNVNKVQELK DKLTELLEEN PDTPEAPRWK QMLTEIDSKW 2520
QELNQLTIDR QQKLEESSNN LTQFQTVEAQ LKQWLVEKEL MVSVLGPLSI DPNMLNTQRQ 2580
QVQILLQEFA TRKPQYEQLT AAGQGILSRP GEDPSLRGIV KEQLAAVTQK WDSLTGQLSD 2640
RCDWIDQAIV KSTQYQSLLR SLSDKLSDLD NKLSSSLAVS THPDAMNQQL ETAQKMKQEI 2700
QQEKKQIKVA QALCEDLSAL VKEEYLKAEL SRQLEGILKS FKDVEQKAEN HVQHLQSACA 2760
SSHQFQQMSR DFQAWLDTKK EEQNKSHPIS AKLDVLESLI KDHKDFSKTL TAQSHMYEKT 2820
IAEGENLLLK TQGSEKAALQ LQLNTIKTNW DTFNKQVKER ENKLKESLEK ALKYKEQVET 2880
LWPWIDKCQN NLEEIKFCLD PAEGENSIAK LKSLQKEMDQ HFGMVELLNN TANSLLSVCE 2940
IDKEVVTDEN KSLIQKVDMV TEQLHSKKFC LENMTQKFKE FQEVSKESKR QLQCAKEQLD 3000
IHDSLGSQAY SNKYLTMLQT QQKSLQALKH QVDLAKRLAQ DLVVEASDSK GTSDVLLQVE 3060
TIAQEHSTLS QQVDEKCSFL ETKLQGIGHF QNTIREMFSQ FAEFDDELDS MAPVGRDAET 3120
LQKQKETIKA FLKKLEALMA SNDNANKTCK MMLATEETSP DLVGIKRDLE ALSKQCNKLL 3180
DRAQAREEQV EGTIKRLEEF YSKLKEFSIL LQKAEEHEES QGPVGMETET INQQLNMFKV 3240
FQKEEIEPLQ GKQQDVNWLG QGLIQSAAKS TSTQGLEHDL DDVNARWKTL NKKVAQRAAQ 3300
LQEALLHCGR FQDALESLLS WMVDTEELVA NQKPPSAEFK VVKAQIQEQK LLQRLLDDRK 3360
STVEVIKREG EKIATTAEPA DKVKILKQLS LLDSRWEALL NKAETRNRQL EGISVVAQQF 3420
HETLEPLNEW LTTIEKRLVN CEPIGTQASK LEEQIAQHKV LQEDILLRKQ NVDQALLNGL 3480
ELLKQTTGDE VLIIQDKLEA IKARYKDITK LSTDVAKTLE QALQLARRLH STHEELCTWL 3540
DKVEVELLSY ETQVLKGEEA SQAQMRPKEL KKEAKNNKAL LDSLNEVSSA LLELVPWRAR 3600
EGLEKMVAED NERYRLVSDT ITQKVEEIDA AILRSQQFDQ AADAELSWIT ETEKKLMSLG 3660
DIRLEQDQTS AQLQVQKTFT MEILRHKDII DDLVKSGHKI MTACSEEEKQ SMKKKLDKVL 3720
KNYDTICQIN SERYLQLERA QSLVNQFWET YEELWPWLTE TQSIISQLPA PALEYETLRQ 3780
QQEEHRQLRE LIAEHKPHID KMNKTGPQLL ELSPGEGFSI QEKYVAADTL YSQIKEDVKK 3840
RAVALDEAIS QSTQFHDKID QILESLERIV ERLRQPPSIS AEVEKIKEQI SENKNVSVDM 3900
EKLQPLYETL KQRGEEMIAR SGGTDKDISA KAVQDKLDQM VFIWENIHTL VEEREAKLLD 3960
VMELAEKFWC DHMSLIVTIK DTQDFIRDLE DPGIDPSVVK QQQEAAETIR EEIDGLQEEL 4020
DIVINLGSEL IAACGEPDKP IVKKSIDELN SAWDSLNKAW KDRIDKLEEA MQAAVQYQDG 4080
LQAVFDWVDI AGGKLASMSP IGTDLETVKQ QIEELKQFKS EAYQQQIEME RLNHQAELLL 4140
KKVTEESDKH TVQDPLMELK LIWDSLEERI INRQHKLEGA LLALGQFQHA LDELLAWLTH 4200
TEGLLSEQKP VGGDPKAIEI ELAKHHVLQN DVLAHQSTVE AVNKAGNDLI ESSAGEEASN 4260
LQNKLEVLNQ RWQNVLEKTE QRKQQLDGAL RQAKGFHGEI EDLQQWLTDT ERHLLASKPL 4320
GGLPETAKEQ LNVHMEVCAA FEAKEETYKS LMQKGQQMLA RCPKSAETNI DQDINNLKEK 4380
WESVETKLNE RKTKLEEALN LAMEFHNSLQ DFINWLTQAE QTLNVASRPS LILDTVLFQI 4440
DEHKVFANEV NSHREQIIEL DKTGTHLKYF SQKQDVVLIK NLLISVQSRW EKVVQRLVER 4500
GRSLDDARKR AKQFHEAWSK LMEWLEESEK SLDSELEIAN DPDKIKTQLA QHKEFQKSLG 4560
AKHSVYDTTN RTGRSLKEKT SLADDNLKLD DMLSELRDKW DTICGKSVER QNKLEEALLF 4620
SGQFTDALQA LIDWLYRVEP QLAEDQPVHG DIDLVMNLID NHKAFQKELG KRTSSVQALK 4680
RSARELIEGS RDDSSWVKVQ MQELSTRWET VCALSISKQT RLEAALRQAE EFHSVVHALL 4740
EWLAEAEQTL RFHGVLPDDE DALRTLIDQH KEFMKKLEEK RAELNKATTM GDTVLAICHP 4800
DSITTIKHWI TIIRARFEEV LAWAKQHQQR LASALAGLIA KQELLEALLA WLQWAETTLT 4860
DKDKEVIPQE IEEVKALIAE HQTFMEEMTR KQPDVDKVTK TYKRRAADPS SLQSHIPVLD 4920
KGRAGRKRFP ASSLYPSGSQ TQIETKNPRV NLLVSKWQQV WLLALERRRK LNDALDRLEE 4980
LREFANFDFD IWRKKYMRWM NHKKSRVMDF FRRIDKDQDG KITRQEFIDG ILSSKFPTSR 5040
LEMSAVADIF DRDGDGYIDY YEFVAALHPN KDAYKPITDA DKIEDEVTRQ VAKCKCAKRF 5100
QVEQIGDNKY RFFLGNQFGD SQQLRLVRIL RSTVMVRVGG GWMALDEFLV KNDPCRVHHH 5160
GSKMLRSESN SSITTTQPTI AKGRTNMELR EKFILADGAS QGMAAFRPRG RRSRPSSRGA 5220
SPNRSTSVSS QAAQAASPQV PATTTPKGTP IQGSKLRLPG YLSGKGFHSG EDSGLITTAA 5280
ARVRTQFADS KKTPSRPGSR AGSKAGSRAS SRRGSDASDF DISEIQSVCS DVETVPQTHR 5340
PTPRAGSRPS TAKPSKIPTP QRKSPASKLD KSSKR 5375 
Gene Ontology
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0007050; P:cell cycle arrest; IEA:InterPro. 
Interpro
 IPR001589; Actinin_actin-bd_CS.
 IPR001715; CH-domain.
 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom.
 IPR003108; GAS2_dom.
 IPR018159; Spectrin/alpha-actinin.
 IPR002017; Spectrin_repeat. 
Pfam
 PF00307; CH
 PF13499; EF_hand_5
 PF02187; GAS2
 PF00435; Spectrin 
SMART
 SM00033; CH
 SM00054; EFh
 SM00243; GAS2
 SM00150; SPEC 
PROSITE
 PS00019; ACTININ_1
 PS00020; ACTININ_2
 PS50021; CH
 PS00018; EF_HAND_1
 PS50222; EF_HAND_2
 PS51460; GAR 
PRINTS