UniProt Accession

 SODE_HUMAN; P08294; Q5U781; Q6FHA2 

Genbank Protein ID

 J02947; U10116; CR541853; AY787834; BC014418 

Genbank Nucleotide ID

 AAA66000.1; AAA62278.1; CAG46651.1; AAV40827.1; AAH14418.1 

Protein Name

 Extracellular superoxide dismutase [Cu-Zn] 

Protein Synonyms/Alias

 EC-SOD 

Gene Name

 SOD3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
229	AREHSERKKRRRESE	glycation	[1]
230	REHSERKKRRRESEC	glycation	[1]

Reference

 [1] The site of nonenzymic glycation of human extracellular-superoxide dismutase in vitro.
 Adachi T, Ohta H, Hayashi K, Hirano K, Marklund SL.
 Free Radic Biol Med. 1992 Sep;13(3):205-10. [PMID: 1505778] 

Functional Description

 Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen. 

Sequence Annotation

 METAL 114 114 Copper; catalytic.
 METAL 116 116 Copper; catalytic.
 METAL 131 131 Copper; catalytic.
 METAL 131 131 Zinc; structural.
 METAL 139 139 Zinc; structural.
 METAL 142 142 Zinc; structural.
 METAL 145 145 Zinc; structural.
 METAL 181 181 Copper; catalytic.
 CARBOHYD 107 107 N-linked (GlcNAc...).
 CARBOHYD 229 229 N-linked (Glc) (glycation); in vitro.
 CARBOHYD 230 230 N-linked (Glc) (glycation); in vitro.
 DISULFID 63 208
 DISULFID 125 207  

Keyword

 3D-structure; Antioxidant; Complete proteome; Copper; Direct protein sequencing; Disulfide bond; Glycation; Glycoprotein; Heparin-binding; Metal-binding; Oxidoreductase; Polymorphism; Reference proteome; Secreted; Signal; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 240 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IBA:RefGenome.
 GO:0031012; C:extracellular matrix; IEA:Compara.
 GO:0005615; C:extracellular space; IDA:BHF-UCL.
 GO:0005739; C:mitochondrion; IBA:RefGenome.
 GO:0005634; C:nucleus; IBA:RefGenome.
 GO:0005802; C:trans-Golgi network; IEA:Compara.
 GO:0005507; F:copper ion binding; IBA:RefGenome.
 GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
 GO:0004784; F:superoxide dismutase activity; IBA:RefGenome.
 GO:0008270; F:zinc ion binding; IBA:RefGenome.
 GO:0019430; P:removal of superoxide radicals; IBA:RefGenome.
 GO:0046688; P:response to copper ion; IEA:Compara.
 GO:0001666; P:response to hypoxia; IEA:Compara. 

Interpro

 IPR024134; SOD_Cu/Zn_/chaperones.
 IPR018152; SOD_Cu/Zn_BS.
 IPR024141; SOD_Cu/Zn_extracel.
 IPR001424; SOD_Cu_Zn_dom. 

Pfam

 PF00080; Sod_Cu 

SMART

  

PROSITE

 PS00087; SOD_CU_ZN_1
 PS00332; SOD_CU_ZN_2 

PRINTS

 PR00068; CUZNDISMTASE.