| Tag | Content |
|---|
| CPLM ID | CPLM-011545 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Sterol esterase 2 |
Protein Synonyms/Alias | Steryl ester hydrolase 2 |
Gene Name | YEH2 |
Gene Synonyms/Alias | YLR020C |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 191 | NDGVEEVKREPILLL | ubiquitination | [1] | | 443 | KTWFPIAKNDDDSGN | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Mediates the hydrolysis of steryl esters. Required for mobilization of steryl ester, thereby playing a central role in lipid metabolism. |
Sequence Annotation | ACT_SITE 287 287 Nucleophile (By similarity).
ACT_SITE 480 480 Charge relay system (By similarity).
ACT_SITE 511 511 Charge relay system (By similarity).
MOD_RES 73 73 Phosphoserine.
MOD_RES 107 107 Phosphoserine. |
Keyword | Cell membrane; Complete proteome; Hydrolase; Lipid degradation; Lipid metabolism; Membrane; Phosphoprotein; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 538 AA |
Protein Sequence | MVNKVVDEVQ RLVSAIILTS FMTGLFILSL WKNYVTVHFQ HKNDPRDTRS SRTKIQPNDK 60
KKKRPARHSR PLSISSTTPL DLQRDQENNI EYDRTVTSKL SMTSNASLSE NGDGNANIKM 120
ETNVNQAPYA AENPFQNIAL AEDTKLVPDL KYYYKEYGID IEEFEVETDD GFIIDLWHFK 180
SRLNDGVEEV KREPILLLHG LLQSCGAFAS SGRKSLAYFL YESGFDVWLG NNRCGLNAKW 240
NMKKLGNDHS KKWDWDMHQM VQYDLKALIN YVLDSTGYAK LSLVAHSQGT TQGFMGLVNG 300
EKLYASDFKL VDKLENFVAL APAVYPGPLL DEKAFVRLMA KGIDSPWYFG RRSFIPLMMT 360
MRKLMVGTKI FSFLSYIMFN YLFDWNDVLW DRVLRDRNFL FSPVHISVKL MQWWLSPLPN 420
KLSFKKGAEK IFPDKKTWFP IAKNDDDSGN NLDNNKLHLN PKRQNSEEFP HIIMFIPKQD 480
RLVDGERLIN HFINHEANAV YKIWYIDEYS HLDVLWAHDV IDRIGKPMIE NLRFPNAR 538 |
Gene Ontology | GO:0016021; C:integral to membrane; IDA:SGD. GO:0005886; C:plasma membrane; IDA:SGD. GO:0004771; F:sterol esterase activity; IDA:SGD. GO:0000032; P:cell wall mannoprotein biosynthetic process; IMP:SGD. GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW. GO:0016125; P:sterol metabolic process; IMP:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |