UniProt Accession

 CENPR_HUMAN; Q13352; B2R7D8; Q13353; Q5RJ42; Q5RJ44; Q5RJ45; Q7KYX2; Q96CD5; Q9UKB6 

Genbank Protein ID

 U37139; U37139; AF175306; AK312944; BX004807; AL592218; BX004807; AL592218; AL592218; BX004807; AL592218; BX004807; BC009929; BC014385 

Genbank Nucleotide ID

 AAC50295.1; AAC50294.1; AAF00239.1; BAG35785.1; CAI15771.1; CAI15771.1; CAI15772.1; CAI15772.1; CAI18958.1; CAI18958.1; CAI18959.1; CAI18959.1; AAH09929.1; AAH14385.1 

Protein Name

 Centromere protein R 

Protein Synonyms/Alias

 CENP-R; Beta-3-endonexin; Integrin beta-3-binding protein; Nuclear receptor-interacting factor 3 

Gene Name

 ITGB3BP 

Gene Synonyms/Alias

 CENPR; NRIF3 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
172	SCASHFLKREMQKTK	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. In contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin D, progesterone receptor, nor glucocorticoid. Acts as a coactivator for estrogen receptor alpha. Acts as a transcriptional corepressor via its interaction with the NFKB1 NF- kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. Induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. May also act as an inhibitor of cyclin A- associated kinase. Also acts a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. 

Sequence Annotation

 REGION 20 50 DD1.
 MOTIF 9 13 LXXLL motif.
 MOTIF 63 66 Nuclear localization signal.
 MOTIF 172 176 LXXIL motif.
 MOD_RES 17 17 Phosphoserine.
 MOD_RES 28 28 Phosphoserine (Probable).
 MOD_RES 71 71 Phosphoserine.  

Keyword

 Activator; Alternative splicing; Apoptosis; Cell cycle; Cell division; Centromere; Chromosome; Coiled coil; Complete proteome; Cytoplasm; Kinetochore; Mitosis; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repressor; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 177 AA 

Protein Sequence

Gene Ontology

 GO:0000777; C:condensed chromosome kinetochore; IEA:UniProtKB-SubCell.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0016020; C:membrane; TAS:ProtInc.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0008022; F:protein C-terminus binding; TAS:ProtInc.
 GO:0004871; F:signal transducer activity; TAS:ProtInc.
 GO:0097190; P:apoptotic signaling pathway; TAS:Reactome.
 GO:0007155; P:cell adhesion; TAS:ProtInc.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0034080; P:CENP-A containing nucleosome assembly at centromere; TAS:Reactome.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW.
 GO:0000278; P:mitotic cell cycle; TAS:Reactome.
 GO:0048011; P:neurotrophin TRK receptor signaling pathway; TAS:Reactome.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR009601; NRIF3_coact_rcpt. 

Pfam

 PF06729; NRIF3 

SMART

  

PROSITE

  

PRINTS