CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002295
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ketol-acid reductoisomerase 
Protein Synonyms/Alias
 Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacyl reductoisomerase 
Gene Name
 ilvC 
Gene Synonyms/Alias
 b3774; JW3747 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
38GASYLQGKKVVIVGCacetylation[1]
69DISYALRKEAIAEKRacetylation[1]
75RKEAIAEKRASWRKAacetylation[1]
88KATENGFKVGTYEELacetylation[1]
123RTVQPLMKDGAALGYacetylation[1]
145EVGEQIRKDITVVMVacetylation[1]
166TEVREEYKRGFGVPTacetylation[1]
184VHPENDPKGEGMAIAacetylation[1]
192GEGMAIAKAWAAATGacetylation[1]
325ADWANDDKKLLTWREacetylation[1]
326DWANDDKKLLTWREEacetylation[1]
336TWREETGKTAFETAPacetylation[1]
348TAPQYEGKIGEQEYFacetylation[1]
357GEQEYFDKGVLMIAMacetylation[1]
446LQPGDLGKAIPEGAVacetylation[1]
475HAIEQVGKKLRGYMTacetylation[1]
485RGYMTDMKRIAVAG*acetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
  
Sequence Annotation
 ACT_SITE 132 132 Potential.  
Keyword
 3D-structure; Amino-acid biosynthesis; Branched-chain amino acid biosynthesis; Complete proteome; Direct protein sequencing; NADP; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 491 AA 
Protein Sequence
MANYFNTLNL RQQLAQLGKC RFMGRDEFAD GASYLQGKKV VIVGCGAQGL NQGLNMRDSG 60
LDISYALRKE AIAEKRASWR KATENGFKVG TYEELIPQAD LVINLTPDKQ HSDVVRTVQP 120
LMKDGAALGY SHGFNIVEVG EQIRKDITVV MVAPKCPGTE VREEYKRGFG VPTLIAVHPE 180
NDPKGEGMAI AKAWAAATGG HRAGVLESSF VAEVKSDLMG EQTILCGMLQ AGSLLCFDKL 240
VEEGTDPAYA EKLIQFGWET ITEALKQGGI TLMMDRLSNP AKLRAYALSE QLKEIMAPLF 300
QKHMDDIISG EFSSGMMADW ANDDKKLLTW REETGKTAFE TAPQYEGKIG EQEYFDKGVL 360
MIAMVKAGVE LAFETMVDSG IIEESAYYES LHELPLIANT IARKRLYEMN VVISDTAEYG 420
NYLFSYACVP LLKPFMAELQ PGDLGKAIPE GAVDNGQLRD VNEAIRSHAI EQVGKKLRGY 480
MTDMKRIAVA G 491 
Gene Ontology
 GO:0005829; C:cytosol; IDA:EcoCyc.
 GO:0004455; F:ketol-acid reductoisomerase activity; IDA:EcoCyc.
 GO:0050661; F:NADP binding; IEA:InterPro.
 GO:0009097; P:isoleucine biosynthetic process; IDA:EcoCyc.
 GO:0009099; P:valine biosynthetic process; IDA:EcoCyc. 
Interpro
 IPR008927; 6-PGluconate_DH_C-like.
 IPR013023; AcH_isomrdctse.
 IPR000506; AcH_isomrdctse_C.
 IPR013328; DH_multihelical.
 IPR013116; IlvN.
 IPR014359; KetolA_reductoisomerase_bac.
 IPR016040; NAD(P)-bd_dom. 
Pfam
 PF01450; IlvC
 PF07991; IlvN 
SMART
  
PROSITE
  
PRINTS