CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040917
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 CDK5 regulatory subunit-associated protein 2 
Protein Synonyms/Alias
  
Gene Name
 CDK5RAP2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
479HNQEQVIKHLTESTNubiquitination[1]
488LTESTNQKDVLLQKFubiquitination[1, 2, 3, 4]
494QKDVLLQKFNEKDLEubiquitination[1, 5]
526SEGLITEKCSSQQPPubiquitination[1, 4]
536SQQPPGSKTIFSKEKubiquitination[1]
541GSKTIFSKEKKQSSDubiquitination[1]
543KTIFSKEKKQSSDYEubiquitination[1]
557EELIQVLKKEQDIYTubiquitination[1]
558ELIQVLKKEQDIYTHubiquitination[1, 4]
568DIYTHLVKSLQESDSubiquitination[1]
585NLQAELNKIFALRKQubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 749 AA 
Protein Sequence
MMDLVLEEDV TVPGTLSGCS GLVPSVPDDL DGINPNAGLG NVLPNVSEET VSPTRARNMK 60
DFENQITELK KENFNLKLRI YFLEERMQQE FHGPTEHIYK TNIELKVEVE SLKRELQERE 120
QLLIKASKAV ESLAEAGGSE IQRVKEDARK KVQQVEDLLT KRILLLEKDV TAAQAELEKA 180
FAGTETEKAL RLRLESKLSE MKKMHEGDLA MALVLDEKDR LIEELKLSLK SKEALIQCLK 240
EEKSQMACPD ENVSSGELRG LCAAPREEKE RETEAAQMEH QKERNSFEER IQALEEDLRE 300
KEREIATEKK NSLKRDKAIQ GLTMALKSKE KKVEELNSEI EKLSAAFAKA REALQKAQTQ 360
EFQGSEDYET ALSGKEALSA ALRSQNLTKS TENHRLRRSI KKITQELSDL QQERERLEKD 420
LEEAHREKSK GDCTIRDLRN EVEKLRNEVN EREKAMENRY KSLLSESNKK LHNQEQVIKH 480
LTESTNQKDV LLQKFNEKDL EVIQQNCYLM AAEDLELRSE GLITEKCSSQ QPPGSKTIFS 540
KEKKQSSDYE ELIQVLKKEQ DIYTHLVKSL QESDSINNLQ AELNKIFALR KQLEQDVLSY 600
QNLRKTLEEQ ISEIRRREEE SFSLYSDQTS YLSICLEENN RFQVEHFSQE ELKKKVSDLI 660
QLVKELYTDN QHLKKTIFDL SCMGFQGNGF PDRLASTEQT ETSLTYSYIF MLHTFLGCIF 720
TPFHAPCSFW LARRTRTRSK LGRMTRLIS 749 
Gene Ontology
  
Interpro
 IPR012943; Spindle_assoc. 
Pfam
 PF07989; Microtub_assoc 
SMART
  
PROSITE
  
PRINTS