UniProt Accession

 ACR_MYCTU; P0A5B7; L0TBA7; P30223 

Genbank Protein ID

 S79751; M76712; AE000516; AL123456 

Genbank Nucleotide ID

 AAB21317.1; AAA25342.1; AAK46369.1; CCP44804.1 

Protein Name

 Alpha-crystallin 

Protein Synonyms/Alias

 Acr; 14 kDa antigen; 16 kDa antigen; HSP 16.3; Nox16 

Gene Name

 hspX 

Gene Synonyms/Alias

 acr; Rv2031c; MT2090; MTV018.18c 

Created Date

 July 27, 2013 

Organism

 Mycobacterium tuberculosis 

NCBI Taxa ID

 1773 

Lysine Modification

Position	Peptide	Type	References
64	LPGVDPDKDVDIMVR	pupylation	[1]
85	KAERTEQKDFDGRSE	pupylation	[1]
114	GADEDDIKATYDKGI	pupylation	[1]
132	SVAVSEGKPTEKHIQ	pupylation	[1]

Reference

 [1] Prokaryotic ubiquitin-like protein (Pup) proteome of Mycobacterium tuberculosis [corrected] .
 Festa RA, McAllister F, Pearce MJ, Mintseris J, Burns KE, Gygi SP, Darwin KH.
 PLoS One. 2010 Jan 6;5(1):e8589. [PMID: 20066036] 

Functional Description

 Acts as a chaperone, as it has a significant ability to suppress the thermal denaturation of alcohol dehydrogenase. Cells overexpressing this gene grow more slowly than wild-type cells, and are less susceptible to autolysis following saturation of the culture in vitro, suggesting this protein may slow down the growth rate of M.tuberculosis in culture and by extension during macrophage infection. 

Sequence Annotation

 CROSSLNK 64 64 Isoglutamyl lysine isopeptide (Lys-Gln)
 CROSSLNK 85 85 Isoglutamyl lysine isopeptide (Lys-Gln)
 CROSSLNK 114 114 Isoglutamyl lysine isopeptide (Lys-Gln)
 CROSSLNK 132 132 Isoglutamyl lysine isopeptide (Lys-Gln)  

Keyword

 Cell wall; Chaperone; Complete proteome; Cytoplasm; Direct protein sequencing; Isopeptide bond; Reference proteome; Secreted; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 144 AA 

Protein Sequence

Gene Ontology

 GO:0005618; C:cell wall; IDA:MTBBASE.
 GO:0005829; C:cytosol; IDA:MTBBASE.
 GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IDA:MTBBASE.
 GO:0044183; F:protein binding involved in protein folding; IDA:MTBBASE.
 GO:0071456; P:cellular response to hypoxia; IEP:MTBBASE.
 GO:0071500; P:cellular response to nitrosative stress; IEP:MTBBASE.
 GO:0009267; P:cellular response to starvation; IEP:MTBBASE.
 GO:0044121; P:growth of symbiont in host organelle; IMP:MTBBASE.
 GO:0045926; P:negative regulation of growth; IMP:MTBBASE.
 GO:0046777; P:protein autophosphorylation; IDA:MTBBASE.
 GO:0051260; P:protein homooligomerization; IPI:MTBBASE.
 GO:0009408; P:response to heat; IDA:MTBBASE.
 GO:0052572; P:response to host immune response; IEP:MTBBASE.
 GO:0010039; P:response to iron ion; IEP:MTBBASE. 

Interpro

 IPR002068; a-crystallin/Hsp20_dom.
 IPR008978; HSP20-like_chaperone. 

Pfam

 PF00011; HSP20 

SMART

  

PROSITE

 PS01031; HSP20 

PRINTS