CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015431
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Seizure 6-like protein 2 
Protein Synonyms/Alias
  
Gene Name
 SEZ6L2 
Gene Synonyms/Alias
 PSK; UNQ1903/PRO4349 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
636QGFVLHFKEVPRNDTubiquitination[1]
873YYTKLQGKSLFGFSGubiquitination[1, 2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
 May contribute to specialized endoplasmic reticulum functions in neurons (By similarity). 
Sequence Annotation
 DOMAIN 173 286 CUB 1.
 DOMAIN 288 347 Sushi 1.
 DOMAIN 349 459 CUB 2.
 DOMAIN 462 525 Sushi 2.
 DOMAIN 527 638 CUB 3.
 DOMAIN 642 701 Sushi 3.
 DOMAIN 703 766 Sushi 4.
 DOMAIN 769 830 Sushi 5.
 REGION 41 48 O-glycosylated at one site.
 CARBOHYD 176 176 N-linked (GlcNAc...) (Potential).
 CARBOHYD 222 222 N-linked (GlcNAc...) (Potential).
 CARBOHYD 247 247 N-linked (GlcNAc...) (Potential).
 CARBOHYD 332 332 N-linked (GlcNAc...) (Potential).
 CARBOHYD 355 355 N-linked (GlcNAc...) (Potential).
 CARBOHYD 373 373 N-linked (GlcNAc...) (Potential).
 CARBOHYD 473 473 N-linked (GlcNAc...) (Potential).
 CARBOHYD 517 517 N-linked (GlcNAc...) (Potential).
 CARBOHYD 641 641 N-linked (GlcNAc...) (Potential).
 DISULFID 173 202 By similarity.
 DISULFID 290 330 By similarity.
 DISULFID 316 345 By similarity.
 DISULFID 349 376 By similarity.
 DISULFID 464 508 By similarity.
 DISULFID 491 523 By similarity.
 DISULFID 527 553 By similarity.
 DISULFID 644 686 By similarity.
 DISULFID 672 699 By similarity.
 DISULFID 705 747 By similarity.
 DISULFID 733 764 By similarity.
 DISULFID 771 813 By similarity.
 DISULFID 799 828 By similarity.  
Keyword
 Alternative splicing; Cell membrane; Complete proteome; Disulfide bond; Endoplasmic reticulum; Glycoprotein; Membrane; Polymorphism; Reference proteome; Repeat; Signal; Sushi; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 910 AA 
Protein Sequence
MGTPRAQHPP PPQLLFLILL SCPWIQGLPL KEEEILPEPG SETPTVASEA LAELLHGALL 60
RRGPEMGYLP GSDRDPTLAT PPAGQTLAVP SLPRATEPGT GPLTTAVTPN GVRGAGPTAP 120
ELLTPPPGTT APPPPSPASP GPPLGPEGGE EETTTTIITT TTVTTTVTSP VLCNNNISEG 180
EGYVESPDLG SPVSRTLGLL DCTYSIHVYP GYGIEIQVQT LNLSQEEELL VLAGGGSPGL 240
APRLLANSSM LGEGQVLRSP TNRLLLHFQS PRVPRGGGFR IHYQAYLLSC GFPPRPAHGD 300
VSVTDLHPGG TATFHCDSGY QLQGEETLIC LNGTRPSWNG ETPSCMASCG GTIHNATLGR 360
IVSPEPGGAV GPNLTCRWVI EAAEGRRLHL HFERVSLDED NDRLMVRSGG SPLSPVIYDS 420
DMDDVPERGL ISDAQSLYVE LLSETPANPL LLSLRFEAFE EDRCFAPFLA HGNVTTTDPE 480
YRPGALATFS CLPGYALEPP GPPNAIECVD PTEPHWNDTE PACKAMCGGE LSEPAGVVLS 540
PDWPQSYSPG QDCVWGVHVQ EEKRILLQVE ILNVREGDML TLFDGDGPSA RVLAQLRGPQ 600
PRRRLLSSGP DLTLQFQAPP GPPNPGLGQG FVLHFKEVPR NDTCPELPPP EWGWRTASHG 660
DLIRGTVLTY QCEPGYELLG SDILTCQWDL SWSAAPPACQ KIMTCADPGE IANGHRTASD 720
AGFPVGSHVQ YRCLPGYSLE GAAMLTCYSR DTGTPKWSDR VPKCALKYEP CLNPGVPENG 780
YQTLYKHHYQ AGESLRFFCY EGFELIGEVT ITCVPGHPSQ WTSQPPLCKV TQTTDPSRQL 840
EGGNLALAIL LPLGLVIVLG SGVYIYYTKL QGKSLFGFSG SHSYSPITVE SDFSNPLYEA 900
GDTREYEVSI 910 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. 
Interpro
 IPR000859; CUB_dom.
 IPR000436; Sushi_SCR_CCP. 
Pfam
 PF00431; CUB
 PF00084; Sushi 
SMART
 SM00032; CCP
 SM00042; CUB 
PROSITE
 PS01180; CUB
 PS50923; SUSHI 
PRINTS