CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030576
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Putative protein arginine N-methyltransferase 10 
Protein Synonyms/Alias
 Putative uncharacterized protein LOC90826; cDNA FLJ39384 fis, clone PLACE5000066 
Gene Name
 LOC90826 
Gene Synonyms/Alias
 PRMT10; hCG_2026199 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
13EAAGYFHKAVKLNPDubiquitination[1]
16GYFHKAVKLNPDFSDubiquitination[1, 2]
25NPDFSDAKENFYRVAubiquitination[1]
48FIMLNDTKRNTIYNAubiquitination[1]
59IYNAAIQKAVCLGSKubiquitination[1]
84ILSMFAKKAGAHSVYubiquitination[1]
111CDVVAANKMEAGIKLubiquitination[1]
117NKMEAGIKLLHTKSLubiquitination[1]
122GIKLLHTKSLDIEIPubiquitination[1, 2, 3, 4]
209RHHRVGIKDIAGIHLubiquitination[1, 2]
243IEPYTTEKMSRVPGGubiquitination[3, 4]
639LPCIPLSKPVELLRLubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Methyltransferase; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 732 AA 
Protein Sequence
MGFRDEAAGY FHKAVKLNPD FSDAKENFYR VANWLVERWH FIMLNDTKRN TIYNAAIQKA 60
VCLGSKSVLD IGAGTGILSM FAKKAGAHSV YACELSKTMY ELACDVVAAN KMEAGIKLLH 120
TKSLDIEIPK HIPERVSLVV TETVDAGLFG EGIVESLIHA WEHLLLQPKT KGESANCEKY 180
GKVIPASAVI FGMAVECAEI RRHHRVGIKD IAGIHLPTNV KFQSPAYSSV DTEETIEPYT 240
TEKMSRVPGG YLALTECFEI MTVDFNNLQE LKSLATKKPD KIGIPVIKEG ILDAIMVWFV 300
LQLDDEHSLS TSPSEETCWE QAVYPVQDLA DYWIKPGDHV MMEVSCQDCY LRIQSISVLG 360
LECEMDVAKS FTQNKDLLSL GNEAELCSAL ANLQTSKPDA VEQTCILEST EIALLNNIPY 420
HEGFKMAMSK VLSSLTPEKL YQTMDTHCQN EMSSGTGQSN TVQNILEPFY VLDVSEGFSV 480
LPVIAGTLGQ VKPYSSVEKD QHRIALDLIS EANHFPKETL EFWLRHVEDE SAMLQRPKSD 540
KLWSIIILDV IEPSGLIQQE IMEKAAISRC LLQSGGKIFP QYVLMFGLLV ESQTLLEENA 600
VQGTERTLGL NIAPFINQFQ VPIRVFLDLS SLPCIPLSKP VELLRLDLMT PYLNTSNREV 660
KVYVCKSGRL TAIPFWYHMY LDEEIRLDTS SEASHWKQAA VVLDNPIQVE MGEELVLSIQ 720
HHKSNVSITV KQ 732 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0008276; F:protein methyltransferase activity; IEA:InterPro. 
Interpro
 IPR025799; Arg_MeTrfase.
 IPR010456; Ribosomal-L11_MeTrfase_PrmA.
 IPR013026; TPR-contain_dom. 
Pfam
 PF06325; PrmA 
SMART
  
PROSITE
 PS50293; TPR_REGION 
PRINTS