UniProt Accession

 DHYS_HUMAN; P49366; A8K688; M0R1I5; Q13184; Q13276; Q9UDG0 

Genbank Protein ID

 L39068; U40579; U32178; U26266; AJ001701; AJ001702; AJ001703; AJ001704; U79262; AL520040; AK291553; AC010422; CH471106; BC000333; BC014016 

Genbank Nucleotide ID

 AAA86282.1; AAA96151.1; AAB02179.1; AAB02175.1; CAA04940.1; CAA04940.1; CAA04940.1; CAA04940.1; AAB50208.1; BAF84242.1; EAW84288.1; AAH00333.1; AAH14016.1 

Protein Name

 Deoxyhypusine synthase 

Protein Synonyms/Alias

 DHS 

Gene Name

 DHPS 

Gene Synonyms/Alias

 DS 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
72	QVNAMIEKKLEPLSQ	ubiquitination	[1]
212	KMIARLGKEINNPES	ubiquitination	[1]
319	MDAFMHEKNED****	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. 

Sequence Annotation

 NP_BIND 105 109 NAD.
 NP_BIND 131 133 NAD.
 NP_BIND 308 309 NAD.
 NP_BIND 342 343 NAD.
 REGION 136 137 Spermidine binding (Probable).
 REGION 314 316 Spermidine binding (Probable).
 REGION 323 329 Spermidine binding (Probable).
 ACT_SITE 329 329 Nucleophile.
 BINDING 137 137 NAD.
 BINDING 238 238 NAD.
 BINDING 243 243 Spermidine (Probable).
 BINDING 283 283 NAD; via amide nitrogen.
 BINDING 288 288 Spermidine (Probable).
 MOD_RES 78 78 Phosphoserine.  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Direct protein sequencing; Hypusine biosynthesis; NAD; Phosphoprotein; Polymorphism; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 369 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0034038; F:deoxyhypusine synthase activity; TAS:Reactome.
 GO:0050983; P:deoxyhypusine biosynthetic process from spermidine; TAS:ProtInc.
 GO:0008612; P:peptidyl-lysine modification to hypusine; TAS:Reactome.
 GO:0008284; P:positive regulation of cell proliferation; TAS:ProtInc.
 GO:0043687; P:post-translational protein modification; TAS:Reactome.
 GO:0051289; P:protein homotetramerization; IEA:Compara.
 GO:0006412; P:translation; TAS:ProtInc. 

Interpro

 IPR002773; Deoxyhypusine_synthase. 

Pfam

 PF01916; DS 

SMART

  

PROSITE

  

PRINTS