UniProt Accession

 GFAP_RAT; P47819; Q7TQ31; Q9R1Q3; Q9Z2S0 

Genbank Protein ID

 U03700; AF028784; AF028784; BC088851; Z48978; AY142198 

Genbank Nucleotide ID

 AAA20540.1; AAD01873.1; AAD01874.2; AAH88851.1; CAA88842.1; AAN87911.1 

Protein Name

 Glial fibrillary acidic protein 

Protein Synonyms/Alias

 GFAP 

Gene Name

 Gfap 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
84	RFASYIEKVRFLEQQ	ubiquitination	[1]
93	RFLEQQNKALAAELN	acetylation	[2]
93	RFLEQQNKALAAELN	ubiquitination	[1]
109	LRAKEPTKLADVYQA	acetylation	[2]
109	LRAKEPTKLADVYQA	ubiquitination	[1]
152	DLGTLRQKLQDETNL	acetylation	[2]
187	ARVDLERKVESLEEE	acetylation	[2]
200	EEIQFLRKIHEEEVR	ubiquitination	[1]
258	TEEWYRSKFADLTDV	acetylation	[2]
258	TEEWYRSKFADLTDV	ubiquitination	[1]
337	EEEGQSLKEEMARHL	acetylation	[2]
337	EEEGQSLKEEMARHL	ubiquitination	[1]
366	IEIATYRKLLEGEEN	acetylation	[2]
366	IEIATYRKLLEGEEN	ubiquitination	[1]
395	RETSLDTKSVSEGHL	ubiquitination	[1]
409	LKRNIVVKTVEMRDG	acetylation	[2]

Reference

 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113]
 [2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 GFAP, a class-III intermediate filament, is a cell- specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells. 

Sequence Annotation

 REGION 1 70 Head.
 REGION 71 375 Rod.
 REGION 71 102 Coil 1A.
 REGION 103 113 Linker 1.
 REGION 114 212 Coil 1B.
 REGION 213 228 Linker 12.
 REGION 229 250 Coil 2A.
 REGION 251 254 Linker 2.
 REGION 255 375 Coil 2B.
 REGION 376 430 Tail.
 MOD_RES 7 7 Phosphothreonine; by AURKB and ROCK1 (By
 MOD_RES 12 12 Phosphoserine; by AURKB and ROCK1 (By
 MOD_RES 36 36 Phosphoserine; by AURKB and ROCK1 (By
 MOD_RES 41 41 Phosphothreonine (By similarity).
 MOD_RES 108 108 Phosphothreonine.
 MOD_RES 381 381 Phosphothreonine.  

Keyword

 Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Direct protein sequencing; Intermediate filament; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 430 AA 

Protein Sequence

Gene Ontology

 GO:0044297; C:cell body; IEA:Compara.
 GO:0042995; C:cell projection; IEA:Compara.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005882; C:intermediate filament; NAS:RGD.
 GO:0016020; C:membrane; IEA:Compara.
 GO:0005178; F:integrin binding; IDA:MGI.
 GO:0005200; F:structural constituent of cytoskeleton; IDA:RGD.
 GO:0014002; P:astrocyte development; IEA:Compara.
 GO:0060020; P:Bergmann glial cell differentiation; IEA:Compara.
 GO:0030198; P:extracellular matrix organization; IEA:Compara.
 GO:0045109; P:intermediate filament organization; IEA:Compara.
 GO:0060291; P:long-term synaptic potentiation; IEA:Compara.
 GO:0010977; P:negative regulation of neuron projection development; IEA:Compara.
 GO:0031102; P:neuron projection regeneration; IEA:Compara.
 GO:0060252; P:positive regulation of glial cell proliferation; IMP:RGD.
 GO:0010625; P:positive regulation of Schwann cell proliferation; IEA:Compara.
 GO:0051580; P:regulation of neurotransmitter uptake; IEA:Compara.
 GO:0009611; P:response to wounding; IDA:RGD. 

Interpro

 IPR016044; F.
 IPR001664; IF.
 IPR018039; Intermediate_filament_CS. 

Pfam

 PF00038; Filament 

SMART

  

PROSITE

 PS00226; IF 

PRINTS