UniProt Accession

 IPYR_DROME; O77460; Q9W150 

Genbank Protein ID

 AF085600; AF085601; AE013599; AY075479 

Genbank Nucleotide ID

 AAC97111.1; AAC97112.1; AAF47227.2; AAL68291.1 

Protein Name

 Inorganic pyrophosphatase 

Protein Synonyms/Alias

 Nucleosome-remodeling factor 38 kDa subunit; Pyrophosphate phospho-hydrolase; PPase 

Gene Name

 Nurf-38 

Gene Synonyms/Alias

 CG4634 

Created Date

 July 27, 2013 

Organism

 Drosophila melanogaster (Fruit fly) 

NCBI Taxa ID

 7227 

Lysine Modification

Position	Peptide	Type	References
70	PSYSLYFKNKCGNVI	acetylation	[1]
306	NSEHVIPKEEAEKIL	acetylation	[1]

Reference

 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 

Functional Description

 Component of NURF (nucleosome remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. NURF is required for homeotic gene expression, proper larval blood cell development, normal male X chromosome morphology, ecdysteroid signaling and metamorphosis. Nurf-38 may have adapted to deliver pyrophosphatase to chromatin to assist in replication or transcription by efficient removal of the inhibitory metabolite. 

Sequence Annotation

 METAL 166 166 Magnesium 1 (By similarity).
 METAL 171 171 Magnesium 1 (By similarity).
 METAL 171 171 Magnesium 2 (By similarity).
 METAL 203 203 Magnesium 1 (By similarity).
 BINDING 129 129 Diphosphate (By similarity).  

Keyword

 Chromatin regulator; Complete proteome; Cytoplasm; Direct protein sequencing; Hydrolase; Magnesium; Metal-binding; Nucleus; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 338 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:FlyBase.
 GO:0016589; C:NURF complex; IDA:FlyBase.
 GO:0004427; F:inorganic diphosphatase activity; IDA:FlyBase.
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0035076; P:ecdysone receptor-mediated signaling pathway; IGI:FlyBase.
 GO:0042766; P:nucleosome mobilization; IDA:FlyBase.
 GO:0006796; P:phosphate-containing compound metabolic process; IEA:InterPro.
 GO:0045747; P:positive regulation of Notch signaling pathway; IGI:FlyBase.
 GO:0035206; P:regulation of hemocyte proliferation; IMP:FlyBase.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IDA:FlyBase. 

Interpro

 IPR008162; Pyrophosphatase. 

Pfam

 PF00719; Pyrophosphatase 

SMART

  

PROSITE

 PS00387; PPASE 

PRINTS