| Tag | Content |
|---|
| CPLM ID | CPLM-018490 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Thioredoxin domain-containing protein 5 |
Protein Synonyms/Alias | Endoplasmic reticulum resident protein 46; ER protein 46; ERp46; Plasma cell-specific thioredoxin-related protein; PC-TRP; Thioredoxin-like protein p46 |
Gene Name | Txndc5 |
Gene Synonyms/Alias | Tlp46 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 136 | KPGQEAVKYQGPRDF | acetylation | [1] |
|
Reference | [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome. Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ. Mol Cell. 2013 Jan 10;49(1):186-99. [ PMID: 23201123] |
Functional Description | Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide- isomerase deficiency in yeast. |
Sequence Annotation | DOMAIN 35 155 Thioredoxin 1.
DOMAIN 156 281 Thioredoxin 2.
DOMAIN 289 417 Thioredoxin 3.
MOTIF 414 417 Prevents secretion from ER (Potential).
DISULFID 75 78 Redox-active (Potential).
DISULFID 203 206 Redox-active (Potential).
DISULFID 335 338 Redox-active (Potential). |
Keyword | Complete proteome; Direct protein sequencing; Disulfide bond; Endoplasmic reticulum; Redox-active center; Reference proteome; Repeat; Signal. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 417 AA |
Protein Sequence | MPPRPGRLLQ PLAGLPALAT LLLLLGARKG ARAQEVEADS GVEQDPHAKH LYTADMFTHG 60
IQSAAHFVMF FAPWCGHCQR LQPTWNDLGD KYNSMEDAKV YVAKVDCTAD SDVCSAQGVR 120
GYPTLKFFKP GQEAVKYQGP RDFETLENWM LQTLNEEPAT PEPEAEPPRA PELKQGLYEL 180
SANNFELHVS QGNHFIKFFA PWCGHCKALA PTWEQLALGL EHSETVKIGK VDCTQHYAVC 240
SEHQVRGYPT LLWFRDGKKV DQYKGKRDLE SLRDYVQSQL QGSEAAPETV EPSEAPVMAA 300
EPTGDKGTVL ALTEKSFEDT IAQGITFVKF YAPWCGHCKN LAPTWEELSK KEFPGLSDVT 360
IAEVDCTAER NVCSKYSVRG YPTLLLFRGG EKVGEHNGGR DLDSLHSFVL RQAKDEL 417 |
Gene Ontology | GO:0005788; C:endoplasmic reticulum lumen; IDA:UniProtKB. GO:0009055; F:electron carrier activity; IEA:InterPro. GO:0016853; F:isomerase activity; IEA:InterPro. GO:0015035; F:protein disulfide oxidoreductase activity; IEA:InterPro. GO:0045454; P:cell redox homeostasis; IEA:InterPro. GO:0006662; P:glycerol ether metabolic process; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |