CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014611
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ATP-binding cassette sub-family G member 1 
Protein Synonyms/Alias
 ATP-binding cassette transporter 8; White protein homolog 
Gene Name
 Abcg1 
Gene Synonyms/Alias
 Abc8; Wht1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
102KGYKTLLKGISGKFNubiquitination[1]
140GYRETGMKGAVLINGubiquitination[1]
354GMCDADYKRDLGGDTubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Transporter involved in macrophage lipid homeostasis. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages. 
Sequence Annotation
 DOMAIN 77 317 ABC transporter.
 DOMAIN 403 661 ABC transmembrane type-2.
 NP_BIND 118 125 ATP (Potential).
 LIPID 30 30 S-palmitoyl cysteine (By similarity).
 LIPID 154 154 S-palmitoyl cysteine (By similarity).
 LIPID 315 315 S-palmitoyl cysteine (By similarity).
 LIPID 394 394 S-palmitoyl cysteine (By similarity).  
Keyword
 ATP-binding; Complete proteome; Lipid transport; Lipoprotein; Membrane; Nucleotide-binding; Palmitate; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 666 AA 
Protein Sequence
MACLMAAFSV GTAMNASSYS AAMTEPKSVC VSVDEVVSSN VDEVETDLLN GHLKKVDNNF 60
TEAQRFSSLP RRAAVNIEFK DLSYSVPEGP WWKKKGYKTL LKGISGKFNS GELVAIMGPS 120
GAGKSTLMNI LAGYRETGMK GAVLINGMPR DLRCFRKVSC YIMQDDMLLP HLTVQEAMMV 180
SAHLKLQEKD EGRREMVKEI LTALGLLPCA NTRTGSLSGG QRKRLAIALE LVNNPPVMFF 240
DEPTSGLDSA SCFQVVSLMK GLAQGGRSIV CTIHQPSAKL FELFDQLYVL SQGQCVYRGK 300
VSNLVPYLRD LGLNCPTYHN PADFVMEVAS GEYGDQNSRL VRAVREGMCD ADYKRDLGGD 360
TDVNPFLWHR PAEEDSASME GCHSFSASCL TQFCILFKRT FLSIMRDSVL THLRITSHIG 420
IGLLIGLLYL GIGNEAKKVL SNSGFLFFSM LFLMFAALMP TVLTFPLEMS VFLREHLNYW 480
YSLKAYYLAK TMADVPFQIM FPVAYCSIVY WMTSQPSDAV RFVLFAALGT MTSLVAQSLG 540
LLIGAASTSL QVATFVGPVT AIPVLLFSGF FVSFDTIPAY LQWMSYISYV RYGFEGVILS 600
IYGLDREDLH CDIAETCHFQ KSEAILRELD VENAKLYLDF IVLGIFFISL RLIAYFVLRY 660
KIRAER 666 
Gene Ontology
 GO:0009897; C:external side of plasma membrane; IDA:BHF-UCL.
 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0055037; C:recycling endosome; IDA:BHF-UCL.
 GO:0043531; F:ADP binding; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0017127; F:cholesterol transporter activity; IEA:Compara.
 GO:0034437; F:glycoprotein transporter activity; IEA:Compara.
 GO:0005548; F:phospholipid transporter activity; IEA:Compara.
 GO:0034041; F:sterol-transporting ATPase activity; IEA:Compara.
 GO:0019534; F:toxin transporter activity; IEA:Compara.
 GO:0042987; P:amyloid precursor protein catabolic process; IEA:Compara.
 GO:0006200; P:ATP catabolic process; IEA:GOC.
 GO:0033344; P:cholesterol efflux; IMP:BHF-UCL.
 GO:0042632; P:cholesterol homeostasis; IEA:Compara.
 GO:0008203; P:cholesterol metabolic process; IEA:Compara.
 GO:0034436; P:glycoprotein transport; IEA:Compara.
 GO:0034375; P:high-density lipoprotein particle remodeling; IMP:BHF-UCL.
 GO:0032367; P:intracellular cholesterol transport; IEA:Compara.
 GO:0034374; P:low-density lipoprotein particle remodeling; IMP:BHF-UCL.
 GO:0010888; P:negative regulation of lipid storage; IMP:BHF-UCL.
 GO:0010745; P:negative regulation of macrophage derived foam cell differentiation; IC:BHF-UCL.
 GO:0033700; P:phospholipid efflux; IEA:Compara.
 GO:0055091; P:phospholipid homeostasis; IEA:Compara.
 GO:0045542; P:positive regulation of cholesterol biosynthetic process; IMP:BHF-UCL.
 GO:0010875; P:positive regulation of cholesterol efflux; IDA:BHF-UCL.
 GO:0010872; P:regulation of cholesterol esterification; IMP:BHF-UCL.
 GO:0006355; P:regulation of transcription, DNA-dependent; IMP:BHF-UCL.
 GO:0055099; P:response to high density lipoprotein particle stimulus; IDA:BHF-UCL.
 GO:0033993; P:response to lipid; IEA:Compara.
 GO:0043691; P:reverse cholesterol transport; IMP:BHF-UCL.
 GO:1901998; P:toxin transport; IEA:GOC. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR013525; ABC_2_trans.
 IPR003439; ABC_transporter-like.
 IPR017871; ABC_transporter_CS.
 IPR020064; ABC_transptr_G1-like.
 IPR027417; P-loop_NTPase.
 IPR005284; Pigment_permease. 
Pfam
 PF01061; ABC2_membrane
 PF00005; ABC_tran 
SMART
 SM00382; AAA 
PROSITE
 PS51012; ABC_TM2
 PS00211; ABC_TRANSPORTER_1
 PS50893; ABC_TRANSPORTER_2 
PRINTS