CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021167
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Actin-related protein 6 
Protein Synonyms/Alias
 hArp6; hARPX 
Gene Name
 ACTR6 
Gene Synonyms/Alias
 CDA12 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
38RSKTARLKTFTANQIubiquitination[1, 2]
49ANQIDEIKDPSGLFYubiquitination[3]
178IRINVGGKLLTNHLKubiquitination[1, 2]
185KLLTNHLKEIISYRQubiquitination[4]
246PDFSTIKKGFCKPREubiquitination[4]
260EEMVLSGKYKSGEQIacetylation[5]
260EEMVLSGKYKSGEQIubiquitination[4]
262MVLSGKYKSGEQILRubiquitination[4]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861
Functional Description
  
Sequence Annotation
 MOD_RES 2 2 N-acetylthreonine.
 MOD_RES 260 260 N6-acetyllysine.  
Keyword
 Acetylation; Complete proteome; Cytoplasm; Cytoskeleton; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 396 AA 
Protein Sequence
MTTLVLDNGA YNAKIGYSHE NVSVIPNCQF RSKTARLKTF TANQIDEIKD PSGLFYILPF 60
QKGYLVNWDV QRQVWDYLFG KEMYQVDFLD TNIIITEPYF NFTSIQESMN EILFEEYQFQ 120
AVLRVNAGAL SAHRYFRDNP SELCCIIVDS GYSFTHIVPY CRSKKKKEAI IRINVGGKLL 180
TNHLKEIISY RQLHVMDETH VINQVKEDVC YVSQDFYRDM DIAKLKGEEN TVMIDYVLPD 240
FSTIKKGFCK PREEMVLSGK YKSGEQILRL ANERFAVPEI LFNPSDIGIQ EMGIPEAIVY 300
SIQNLPEEMQ PHFFKNIVLT GGNSLFPGFR DRVYSEVRCL TPTDYDVSVV LPENPITYAW 360
EGGKLISEND DFEDMVVTRE DYEENGHSVC EEKFDI 396 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell. 
Interpro
 IPR004000; Actin-related. 
Pfam
 PF00022; Actin 
SMART
 SM00268; ACTIN 
PROSITE
  
PRINTS