CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016329
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Kinesin-like protein KIF18B 
Protein Synonyms/Alias
  
Gene Name
 KIF18B 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
62DGGFPGLKWGGTHDGubiquitination[1]
75DGPKKKGKDLTFVFDubiquitination[1]
316HVPYRDSKLTRLLKDubiquitination[1]
322SKLTRLLKDSLGGNCubiquitination[1]
352EDTYNTLKYADRAKEubiquitination[1]
395EVAALRKKLQVYEGGubiquitination[1]
531RSKQLALKVLCVAQRubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Its major role may be to transport KIF2C and/or MAPRE1 along microtubules. 
Sequence Annotation
 DOMAIN 13 288 Kinesin-motor.
 NP_BIND 118 125 ATP (Potential).
 REGION 723 748 KIF2C-binding.
 MOTIF 636 644 Nuclear localization signal (Probable).
 MOTIF 665 668 MAPRE1-binding.
 MOTIF 786 789 MAPRE1-binding.
 MOTIF 812 815 MAPRE1-binding.
 MOD_RES 413 413 Phosphoserine.
 MOD_RES 438 438 Phosphothreonine.
 MOD_RES 473 473 Phosphoserine.
 MOD_RES 501 501 Phosphoserine.
 MOD_RES 645 645 Phosphoserine.
 MOD_RES 651 651 Phosphoserine.
 MOD_RES 674 674 Phosphoserine.
 MOD_RES 834 834 Phosphoserine.  
Keyword
 Alternative splicing; ATP-binding; Cell cycle; Cell division; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Microtubule; Mitosis; Motor protein; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 864 AA 
Protein Sequence
MSHPGVTTVM AVEDSTLQVV VRVRPPTPRE LDSQRRPVVQ VVDERVLVFN PEEPDGGFPG 60
LKWGGTHDGP KKKGKDLTFV FDRVFGEAAT QQDVFQHTTH SVLDSFLQGY NCSVFAYGAT 120
GAGKTHTMLG REGDPGIMYL TTVELYRRLE ARQQEKHFEV LISYQEVYNE QIHDLLEPKG 180
PLAIREDPDK GVVVQGLSFH QPASAEQLLE ILTRGNRNRT QHPTDANATS SRSHAIFQIF 240
VKQQDRVPGL TQAVQVAKMS LIDLAGSERA SSTHAKGERL REGANINRSL LALINVLNAL 300
ADAKGRKTHV PYRDSKLTRL LKDSLGGNCR TVMIAAISPS SLTYEDTYNT LKYADRAKEI 360
RLSLKSNVTS LDCHISQYAT ICQQLQAEVA ALRKKLQVYE GGGQPPPQDL PGSPKSGPPP 420
EHLPSSPLPP HPPSQPCTPE LPAGPRALQE ESLGMEAQVE RAMEGNSSDQ EQSPEDEDEG 480
PAEEVPTQMP EQNPTHALPE SPRLTLQPKP VVGHFSAREL DGDRSKQLAL KVLCVAQRQY 540
SLLQAANLLT PDMITEFETL QQLVQEEKIE PGAEALRTSG LARGAPLAQE LCSESIPVPS 600
PLCPEPPGYT GPVTRTMARR LSGPLHTLGI PPGPNCTPAQ GSRWPMEKKR RRPSALEADS 660
PMAPKRGTKR QRQSFLPCLR RGSLPDTQPS QGPSTPKGER ASSPCHSPRV CPATVIKSRV 720
PLGPSAMQNC STPLALPTRD LNATFDLSEE PPSKPSFHEC IGWDKIPQEL SRLDQPFIPR 780
APVPLFTMKG PKPTSSLPGT SACKKKRVAS SSVSHGRSRI ARLPSSTLKR PAGPLVLPEL 840
PLSPLCPSNR RNGKDLIRVG RALSAGNGVT KVS 873 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0005875; C:microtubule associated complex; IEA:InterPro.
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003777; F:microtubule motor activity; IEA:InterPro.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0007018; P:microtubule-based movement; IEA:InterPro.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW.
 GO:0000278; P:mitotic cell cycle; IDA:UniProtKB.
 GO:0051302; P:regulation of cell division; IDA:UniProtKB. 
Interpro
 IPR019821; Kinesin_motor_CS.
 IPR001752; Kinesin_motor_dom.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00225; Kinesin 
SMART
 SM00129; KISc 
PROSITE
 PS00411; KINESIN_MOTOR_DOMAIN1
 PS50067; KINESIN_MOTOR_DOMAIN2 
PRINTS
 PR00380; KINESINHEAVY.