UniProt Accession

 DLG1_MOUSE; Q811D0; Q62402; Q6PGB5; Q8CGN7 

Genbank Protein ID

 U93309; AY159380; BC047142; BC057118 

Genbank Nucleotide ID

 AAC31653.1; AAN87264.1; AAH47142.1; AAH57118.1 

Protein Name

 Disks large homolog 1 

Protein Synonyms/Alias

 Embryo-dlg/synapse-associated protein 97; E-dlg/SAP97; Synapse-associated protein 97; SAP-97; SAP97 

Gene Name

 Dlg1 

Gene Synonyms/Alias

 Dlgh1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
725	VIILGPMKDRVNDDL	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Essential multidomain scaffolding protein required for normal development. Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels (By similarity). Functional regulator of Kv1.5 channel (By similarity). May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. 

Sequence Annotation

 DOMAIN 4 64 L27.
 DOMAIN 224 311 PDZ 1.
 DOMAIN 319 406 PDZ 2.
 DOMAIN 466 547 PDZ 3.
 DOMAIN 581 651 SH3.
 DOMAIN 715 890 Guanylate kinase-like.
 REGION 162 212 Interaction with SH3 domains (By
 MOD_RES 122 122 Phosphoserine (By similarity).
 MOD_RES 158 158 Phosphoserine (By similarity).
 MOD_RES 232 232 Phosphoserine (By similarity).
 MOD_RES 301 301 Phosphoserine.
 MOD_RES 399 399 Phosphotyrosine.
 MOD_RES 568 568 Phosphoserine (By similarity).
 MOD_RES 575 575 Phosphoserine (By similarity).
 MOD_RES 619 619 Phosphoserine (By similarity).
 MOD_RES 684 684 Phosphothreonine.
 MOD_RES 685 685 Phosphoserine (By similarity).
 MOD_RES 688 688 Phosphoserine.  

Keyword

 Alternative splicing; Cell junction; Cell membrane; Complete proteome; Endoplasmic reticulum; Membrane; Phosphoprotein; Postsynaptic cell membrane; Reference proteome; Repeat; SH3 domain; Synapse. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 905 AA 

Protein Sequence

Gene Ontology

 GO:0016323; C:basolateral plasma membrane; ISS:UniProtKB.
 GO:0031253; C:cell projection membrane; IDA:MGI.
 GO:0005913; C:cell-cell adherens junction; TAS:UniProtKB.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0001772; C:immunological synapse; IDA:MGI.
 GO:0009898; C:internal side of plasma membrane; IEA:Compara.
 GO:0043219; C:lateral loop; IDA:BHF-UCL.
 GO:0016328; C:lateral plasma membrane; IDA:MGI.
 GO:0045121; C:membrane raft; IDA:MGI.
 GO:0005874; C:microtubule; IEA:Compara.
 GO:0097025; C:MPP7-DLG1-LIN7 complex; IEA:Compara.
 GO:0035748; C:myelin sheath abaxonal region; IDA:BHF-UCL.
 GO:0031594; C:neuromuscular junction; IDA:MGI.
 GO:0033268; C:node of Ranvier; IDA:BHF-UCL.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0014069; C:postsynaptic density; IDA:MGI.
 GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
 GO:0005923; C:tight junction; IEA:Compara.
 GO:0019902; F:phosphatase binding; ISS:UniProtKB.
 GO:0032947; F:protein complex scaffold; IMP:MGI.
 GO:0019901; F:protein kinase binding; ISS:UniProtKB.
 GO:0007015; P:actin filament organization; ISS:UniProtKB.
 GO:0032147; P:activation of protein kinase activity; IMP:MGI.
 GO:0042982; P:amyloid precursor protein metabolic process; IGI:MGI.
 GO:0001658; P:branching involved in ureteric bud morphogenesis; IMP:MGI.
 GO:0016337; P:cell-cell adhesion; ISS:UniProtKB.
 GO:0030866; P:cortical actin cytoskeleton organization; ISS:UniProtKB.
 GO:0048704; P:embryonic skeletal system morphogenesis; IMP:MGI.
 GO:0001935; P:endothelial cell proliferation; ISS:UniProtKB.
 GO:0060022; P:hard palate development; IMP:MGI.
 GO:0001771; P:immunological synapse formation; IMP:MGI.
 GO:0002088; P:lens development in camera-type eye; IMP:MGI.
 GO:0031579; P:membrane raft organization; IMP:MGI.
 GO:0050680; P:negative regulation of epithelial cell proliferation; IMP:MGI.
 GO:0045930; P:negative regulation of mitotic cell cycle; ISS:UniProtKB.
 GO:0042130; P:negative regulation of T cell proliferation; IMP:MGI.
 GO:0030432; P:peristalsis; IMP:MGI.
 GO:0030838; P:positive regulation of actin filament polymerization; IMP:MGI.
 GO:0008284; P:positive regulation of cell proliferation; IMP:MGI.
 GO:0048639; P:positive regulation of developmental growth; TAS:UniProtKB.
 GO:0090004; P:positive regulation of establishment of protein localization to plasma membrane; IEA:Compara.
 GO:0040018; P:positive regulation of multicellular organism growth; TAS:UniProtKB.
 GO:0043268; P:positive regulation of potassium ion transport; IEA:Compara.
 GO:0008104; P:protein localization; IMP:MGI.
 GO:0072659; P:protein localization to plasma membrane; IEA:Compara.
 GO:0042391; P:regulation of membrane potential; IGI:MGI.
 GO:0048608; P:reproductive structure development; IMP:MGI.
 GO:0048745; P:smooth muscle tissue development; IMP:MGI.
 GO:0042110; P:T cell activation; IMP:MGI.
 GO:0002369; P:T cell cytokine production; IMP:MGI.
 GO:0070830; P:tight junction assembly; IEA:Compara. 

Interpro

 IPR008144; Guanylate_kin.
 IPR008145; Guanylate_kin/L-typ_Ca_channel.
 IPR020590; Guanylate_kinase_CS.
 IPR004172; L27.
 IPR015143; L27_1.
 IPR016313; M-assoc_guanylate_kinase.
 IPR019590; MAGUK_PEST_N.
 IPR027417; P-loop_NTPase.
 IPR001478; PDZ.
 IPR019583; PDZ_assoc.
 IPR011511; SH3_2.
 IPR001452; SH3_domain. 

Pfam

 PF00625; Guanylate_kin
 PF09058; L27_1
 PF10608; MAGUK_N_PEST
 PF00595; PDZ
 PF10600; PDZ_assoc
 PF07653; SH3_2 

SMART

 SM00072; GuKc
 SM00569; L27
 SM00228; PDZ
 SM00326; SH3 

PROSITE

 PS00856; GUANYLATE_KINASE_1
 PS50052; GUANYLATE_KINASE_2
 PS51022; L27
 PS50106; PDZ
 PS50002; SH3 

PRINTS